General Information of MET (ID: META00506)
Name Solanidine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(3beta)-Solanid-5-en-3-ol; 22R,25S-Solanidanine; 22R,25S-Solanidine; 3-b-Solanid-5-en-3-ol(9CL); 3-beta-Solanid-5-en-3-ol; 3-beta-Solanid-5-en-3-ol(9CL); Solanid-5-en-3-beta-ol; Solanid-5-en-3-ol; Solanid-5-en-3-ol (acd/name 4.0); Solanid-5-en-3.beta.-ol; Solanid-5-en-3beta-ol; Solanid-5-en-3beta-ol(8ci); Solanidin; Solatubin; Solatubine
Source Endogenous;Drug;Sterol lipids;Food;TCM Ingredients;Plant Metabolite
Structure Type   Steroidal alkaloids  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Steroids and steroid derivatives
Steroidal alkaloids
PubChem CID
65727
HMDB ID
HMDB0003236
Formula
C27H43NO
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=65727"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C06543
ChEBI ID
28374
FooDB ID
FDB012098
ChemSpider ID
59150
METLIN ID
3517
Physicochemical Properties Molecular Weight 397.6 Topological Polar Surface Area 23.5
XlogP 6.1 Complexity 715
Heavy Atom Count 29 Rotatable Bond Count N.A.
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Function
Solanidine is a steroidal alkaloid, and its glycosides have been reported to have caused poisoning in man and animals. Solanidine is present in sera of healthy individuals and in amounts dependent on their dietary potato consumption.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change Solanidine concentration: increase (FC = 3.39)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the increase of solanidine levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

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