Details of Metabolite

General Information of MET (ID: META00502)
Name N-Methylnicotinamide
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3-(Methylcarbamoyl)pyridine; 3-(N-Methylcarbamoyl)pyridine; N -Methyl nicotineamide; N-METHYL-nicotinamide; N-Methyl nicotineamide; N-Methyl-3-pyridinecarboxamide; N-Methylnicotinamide monohydrochloride; N-Methylpyridine-3-carboxamide; Nicotinate methylamide; Nicotinic acid methylamide
Source Endogenous;Food;Microbial
Structure Type   Pyridinecarboxylic acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Pyridines and derivatives
Pyridinecarboxylic acids and derivatives
PubChem CID
64950
HMDB ID
HMDB0003152
Formula
C7H8N2O
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
DrugBank ID
DB08840
ChEBI ID
64399
FooDB ID
FDB023115
ChemSpider ID
58476
Physicochemical Properties Molecular Weight 136.15 Topological Polar Surface Area 42
XlogP N.A. Complexity 125
Heavy Atom Count 10 Rotatable Bond Count 1
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Function
N-methylnicotinamide is a metabolite of niacin (or nicotinamide) and is commonly found in human urine. However low levels of urinary excretion of N-methylnicotinamide indicates niacin deficiency. In patients with liver cirrhosis nicotinamide methylation is increased leading to a rise in urinary N-methylnicotinamide. The hyperfunction of this methylating pathway might play a protective role against the toxic effect of intracellular accumulation of nicotinamide deriving from the catabolic state of cirrhosis. N-methylnicotinamide is known to inhibit choline transport and reduce choline clearance out of the brain. N-methylnicotinamide has been found to be a microbial metabolite.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change N-Methylnicotinamide concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of N-methylnicotinamide levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.

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