General Information of MET (ID: META00497)
Name O-Acetylserine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
L-Serine, acetate (ester); L-Serine, acetic acid (ester); O-Acetyl-L-serine; O-Acetyl-serine; O-Acetylserine; O-Acetylserine hydrobromide, (D)-isomer; O-Acetylserine, (L)-isomer; O3-Acetyl-L-serine; Serine acetate ester
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Drug
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
99478
HMDB ID
HMDB0003011
Formula
C5H9NO4
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00979
DrugBank ID
DB01837
ChEBI ID
17981
FooDB ID
FDB031064
ChemSpider ID
89874
METLIN ID
3270
Physicochemical Properties Molecular Weight 147.13 Topological Polar Surface Area 89.6
XlogP -3.5 Complexity 145
Heavy Atom Count 10 Rotatable Bond Count 4
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 5
Function
O-Acetylserine (OASS) is an acylated amino acid derivative. It is an intermediate in the biosynthesis of the common amino acid cysteine in bacteria and plants. Its presence in humans arises from either microbial metabolism in the gut or through consumption of foods containing OASS.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change O-Acetylserine concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of o-acetylserine levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.

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