Details of Metabolite

General Information of MET (ID: META00492)
Name Docosatrienoic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(13Z,16Z,19Z) Docosatrienoate; (13Z,16Z,19Z) Docosatrienoic acid; (13Z,16Z,19Z)-13,16,19-Docosatrienoic acid; (13Z,16Z,19Z)-Docosatrienoate; 13,16,19-Docosatrienoate; 13,16,19-Docosatrienoic acid; Docosatrienoate; Docosatrienoic acid; FA(22:3(13Z,16Z,19Z)); FA(22:3n3); all-cis-13,16,19 Docosatrienoate; all-cis-13,16,19 Docosatrienoic acid; cis-13,cis-16,cis-19-Docosatrienoic acid
Source Endogenous;Fatty acyls;Food
Structure Type   Fatty acids and conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acids and conjugates
PubChem CID
5312557
HMDB ID
HMDB0002823
Formula
C22H38O2
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
77807
FooDB ID
FDB019146
ChemSpider ID
4471982
METLIN ID
195
Physicochemical Properties Molecular Weight 334.5 Topological Polar Surface Area 37.3
XlogP 8 Complexity 353
Heavy Atom Count 24 Rotatable Bond Count 17
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Function
Docosatrienoic acid, also known as docosatrienoate, belongs to the class of organic compounds known as very long-chain fatty acids. These are fatty acids with an aliphatic tail that contains at least 22 carbon atoms. Docosatrienoic acid is a very hydrophobic molecule, is practically insoluble (in water), and is relatively neutral. Application of docosatrienoic acid was shown to dose-dependently decrease the peak K+ current amplitude and accelerate the potassium activation and inactivation kinetics at all membrane potentials.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change Docosatrienoic acid concentration: increase (FC = 2.20)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the increase of docosatrienoic acid levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.

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