Details of Metabolite

General Information of MET (ID: META00491)
Name N-Acetylglucosamine 6-phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Glcnac6p; N-Acetylglucosamine 6-phosphoric acid
Source Endogenous;Escherichia Coli Metabolite;Food
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
439219
HMDB ID
HMDB0002817
Formula
C8H16NO9P
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=439219"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
FooDB ID
FDB023067
ChemSpider ID
388358
METLIN ID
3429
Physicochemical Properties Molecular Weight 301.19 Topological Polar Surface Area 166
XlogP -4.2 Complexity 371
Heavy Atom Count 19 Rotatable Bond Count 4
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 9
Function
N-Acetylglucosamine 6-phosphate is a monosaccharide derivative of glucose, a main component of the peptidoglycan cell wall in bacteria. GlcNAc is also of note in neurotransmission, where it is thought to be an atypical neurotransmitter functioning in nocioceptive (pain) pathways. N-Acetylglucosamine 6-phosphate has been identified in the human placenta.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Transferases (EC 2)
            Acetylglucosaminyltransferase 5 (MGAT5) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Mgat5
                      Induced Change N-Acetylglucosamine 6-phosphate concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Mgat5 leads to the decrease of N-acetylglucosamine 6-phosphate levels compared with control group.
References
1 N-glycan remodeling on glucagon receptor is an effector of nutrient sensing by the hexosamine biosynthesis pathway. J Biol Chem. 2014 Jun 6;289(23):15927-41.

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