Details of Metabolite

General Information of MET (ID: META00472)
Name Methylcysteine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2R)-2-Amino-3-(methylsulfanyl)propanoate; (2R)-2-Amino-3-(methylsulfanyl)propanoic acid; (2R)-2-Amino-3-(methylsulphanyl)propanoate; (2R)-2-Amino-3-(methylsulphanyl)propanoic acid; (R)-2-Amino-3-(methylthio)propanoate; (R)-2-Amino-3-(methylthio)propanoic acid; 3-(Methylthio)-L-(8ci)alanine; 3-(Methylthio)-L-alanine; Acm-thiopropionate; Acm-thiopropionic acid; L-Aspartic acid dimethyl ester; L-Methylcysteine; S-11C-Methyl-L-cysteine; S-Acetamidomethyl-deamino-cysteine; S-Methyl-(9ci)-L-cysteine; S-Methyl-DL-cysteine; S-Methyl-L-cysteine; S-Methyl-cysteine; S-Methylcysteine; S-Methylcysteine, (DL-cys)-isomer; S-Methylcysteine, (L-cys)-isomer; S-Methylcysteine, hydrochloride, (L-cys)-isomer
Source Food;Drug;TCM Ingredients
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
24417
HMDB ID
HMDB0002108
Formula
C4H9NO2S
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=24417"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
45658
FooDB ID
FDB003689
ChemSpider ID
22826
METLIN ID
6490
Physicochemical Properties Molecular Weight 135.19 Topological Polar Surface Area 88.6
XlogP -2.7 Complexity 86.1
Heavy Atom Count 8 Rotatable Bond Count 3
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4
Function
Methylcysteine is one of the identified number of bioactive substances in garlic that are water soluble. It has been suggested that the use of these organosulfur agents derived from garlic could protect partially oxidized and glycated LDL or plasma against further oxidative and glycative deterioration, which might benefit patients with diabetic-related vascular diseases. It may also exert some chemopreventive effects on chemical carcinogenesis. However, it should be borne in mind that may also demonstrate promotion potential, depending on the organ examined. Methylcystein is a biomarker for the consumption of dried and cooked beans
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change Methylcysteine concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of methylcysteine levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.

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