Details of Metabolite

General Information of MET (ID: META00467)
Name Imidazoleacetic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1H-Imidazol-4-ylacetic acid; 1H-Imidazole-4-acetate; 1H-Imidazole-4-acetic acid; 4(5)-Imidazoleacetate; 4(5)-Imidazoleacetic acid; 4-Imidazoleacetate; 4-Imidazoleacetic acid; IAA; IMAC; IZC; Imidazol-4-ylacetate; Imidazol-4-ylacetic acid; Imidazole acetate; Imidazole-4-acetate; Imidazole-4-acetic acid; Imidazole-4-acetic acid hydrochloride; Imidazole-4-acetic acid, sodium salt; Imidazoleacetate; Imidazolyl-4-acetic acid; Lopac-I-0375
Source Endogenous;Food
Structure Type   Imidazoles  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Azoles
Imidazoles
PubChem CID
96215
HMDB ID
HMDB0002024
Formula
C5H6N2O2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C02835
ChEBI ID
16974
FooDB ID
FDB030508
ChemSpider ID
86856
METLIN ID
6445
Physicochemical Properties Molecular Weight 126.11 Topological Polar Surface Area 66
XlogP -0.4 Complexity 116
Heavy Atom Count 9 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Function
Imidazoleacetic acid is a metabolite product of Histamine metabolism. It is present in normal urine and increased in histidinemic patients. Imidazoleacetic acid has been identified in the human placenta.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change Imidazoleacetic acid concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of imidazoleacetic acid levels compared with control group.
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of TP53
                      Induced Change Imidazoleacetic acid concentration: increase (Log2 FC=1.09)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of imidazoleacetic acid levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.
2 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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