Details of Metabolite

General Information of MET (ID: META00460)
Name Docosapentaenoic acid (22n-6)
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(4Z,7Z,10Z,13Z,16Z)-4,7,10,13,16-Docosapentaenoic acid; (all-Z)-4,7,10,13,16-Docosapentaenoate; (all-Z)-4,7,10,13,16-Docosapentaenoic acid; (all-Z)-7, 10, 13, 16, 19-Docosapentaenoic acid; 22:5(4Z,7Z,10Z,13Z,16Z); 4Z,7Z,10Z,13Z,16Z-Docosapentaenoate; 4Z,7Z,10Z,13Z,16Z-Docosapentaenoic acid; DPA; DPAn-6; Docosa-4,7,10,13,16-pentaenoic acid; Docosa-4,7,10,13,16-pentaenoic acid, (all-Z)-isomer; Docosapentaenoate; Docosapentaenoate (22N-6); Docosapentaenoic acid; Docosapentaenoic acid (C22:5 N6); Docosapentaenoic acid, (all Z)-isomer; FA(22:5(4Z,7Z,10Z,13Z,16Z)); FA(22:5n6); Osbond acid; all-cis-Docosa-4,7,10,13,16-pentaenoate; all-cis-Docosa-4,7,10,13,16-pentaenoic acid
Source Endogenous;Fatty acyls;Food
Structure Type   Fatty acids and conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Fatty Acyls
Fatty acids and conjugates
PubChem CID
6441454
HMDB ID
HMDB0001976
Formula
C22H34O2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
ChEBI ID
65136
FooDB ID
FDB022774
ChemSpider ID
4945614
METLIN ID
6412
Physicochemical Properties Molecular Weight 330.5 Topological Polar Surface Area 37.3
XlogP 6.9 Complexity 425
Heavy Atom Count 24 Rotatable Bond Count 15
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Function
Docosapentaenoic acid is an unsaturated fatty acid found in fish oils. It is a minor constituent of the total serum unsaturated fatty acids in humans. Docosapentaenoic acid (22n-6) is practically insoluble (in water) and a weakly acidic compound (based on its pKa). Docosapentaenoic acid (22n-6) can be found in blood and urine, as well as in human adipose tissue, fibroblasts, and platelet tissues. Within the cell, docosapentaenoic acid (22n-6) is primarily located in the membrane (predicted from logP). It can also be found in the extracellular space. In humans, docosapentaenoic acid (22n-6) is involved in alpha-linolenic acid and linoleic acid metabolism. Docosapentaenoic acid (22n-6) is found to be associated with thyroid cancer.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Group 10 secretory phospholipase A2 (PLA2G10) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Pla2g10
                      Induced Change Docosapentaenoic acid (22n-6) concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Inflammatory bowel disease [ICD-11: DD72]
                      Details It is reported that knockout of Pla2g10 leads to the decrease of docosapentaenoic acid (22n-6) levels compared with control group.
References
1 Group X Secreted Phospholipase A2 Releases 3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility. J Biol Chem. 2016 Mar 25;291(13):6895-911.

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