Details of Metabolite

General Information of MET (ID: META00447)
Name Thymidine 3',5'-cyclic monophosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
CTMP', Cyclic 3',5'-dTMP, Cyclic 3',5'-thymidylate, Cyclic 3',5'-thymidylic acid, 'Cyclic TMP; Thymidine 3',5'-cyclic monophosphoric acid, 3',5'-Cyclic thymidine monophosphate, 3',5'-Cyclic TMP, '4H-Furo[3,2-D]-1,3,2-dioxaphosphorin thymidine deriv.; Thymidine 3,5-cyclic monophosphate sodium salt', Thymidine cyclic 3',5'-phosphate, 'Thymidine cyclophosphate; Thymidine phosphate (cyclic)', 3',5'-Cyclic dTMP, Cyclic 3',5'-thymidine monophosphate
Source Endogenous;Food;Microbial
Structure Type   Pyrimidines and pyrimidine derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Diazines
Pyrimidines and pyrimidine derivatives
PubChem CID
53477735
HMDB ID
HMDB0001570
Formula
C10H13N2O7P
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00364
ChEBI ID
17013
FooDB ID
FDB022695
Physicochemical Properties Molecular Weight 304.19 Topological Polar Surface Area 114
XlogP -1.6 Complexity 548
Heavy Atom Count 20 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 7
Function
Thymidine 3',5'-cyclic monophosphate is an intermediate in the Pyrimidine metabolism. Is the product or substrate of the enzymes Thymidylate synthase (EC 2.1.1.45), Thymidylate synthase (FAD) (EC 2.1.1.148), Thymidine kinase (EC 2.7.1.21), AMP-thymidine kinase (EC 2.7.1.114), ADP-thymidine kinase (EC 2.7.1.118), dTMP kinase (EC 2.7.4.9), T2-induced deoxynucleotide kinase (EC 2.7.4.12), 5'-nucleotidase (EC 3.1.3.5), Thymidylate 5'-phosphatase (EC 3.1.3.35), and ATP-diphosphatase (EC 3.6.1.5). (KEGG).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change Thymidine 3',5'-cyclic monophosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of thymidine 3',5'-cyclic monophosphate levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.

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