Details of Metabolite

General Information of MET (ID: META00434)
Name 3-Hydroxyanthranilic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-Amino-3-hydroxy-benzoate; 2-Amino-3-hydroxy-benzoic acid; 2-Amino-3-hydroxybenzoate; 2-Amino-3-hydroxybenzoic acid; 3 Hydroxyanthranilic acid; 3-Hydroxanthranilate; 3-Hydroxy-2-aminobenzoate; 3-Hydroxy-2-aminobenzoic acid; 3-Hydroxy-anthranilate; 3-Hydroxy-anthranilic acid; 3-Hydroxy-anthranilsaeure; 3-Hydroxyanthranilate; 3-Hydroxyantranilic acid; 3-OH-Anthranilic acid; 3-Ohaa; 3-Oxyanthranilate; 3-Oxyanthranilic acid; Acid, 3-hydroxyanthranilic
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Drug;TCM Ingredients;Microbial
Structure Type   Benzoic acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Benzenoids
Benzene and substituted derivatives
Benzoic acids and derivatives
PubChem CID
86
HMDB ID
HMDB0001476
Formula
C7H7NO3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00632
DrugBank ID
DB03644
ChEBI ID
15793
FooDB ID
FDB010582
ChemSpider ID
84
METLIN ID
3275
Physicochemical Properties Molecular Weight 153.14 Topological Polar Surface Area 83.6
XlogP 0.9 Complexity 160
Heavy Atom Count 11 Rotatable Bond Count 1
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Function
3-Hydroxyanthranilic acid is an oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Oxidoreductases (EC 1)
            3-hydroxyanthranilate oxygenase (HAAO) Click to Show/Hide the Full List of Regulating Pair(s):   3 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Haao
                      Induced Change 3-Hydroxyanthranilic acid concentration: increase (FC > 100)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hereditary methemoglobinemia [ICD-11: 3A92]
                      Details It is reported that knockout of Haao leads to the increase of 3-hydroxyanthranilic acid levels compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (c.483dupT) of HAAO
                      Induced Change 3-Hydroxyanthranilic acid concentration: increase (FC = 63.6)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hereditary methemoglobinemia [ICD-11: 3A92]
                      Details It is reported that mutation (c.483dupT) of HAAO leads to the increase of 3-hydroxyanthranilic acid levels compared with control group.
               Regulating Pair (3) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (c.558G-A) of HAAO
                      Induced Change 3-Hydroxyanthranilic acid concentration: increase (FC = 384.9)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hereditary methemoglobinemia [ICD-11: 3A92]
                      Details It is reported that mutation (c.558G-A) of HAAO leads to the increase of 3-hydroxyanthranilic acid levels compared with control group.
References
1 NAD Deficiency, Congenital Malformations, and Niacin Supplementation. N Engl J Med. 2017 Aug 10;377(6):544-552.

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