Details of Metabolite

General Information of MET (ID: META00418)
Name Sphinganine 1-phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2S,3R)-2-Amino-3-hydroxyoctadecyl dihydrogen phosphate; (2S,3R)-2-Amino-3-hydroxyoctadecyl dihydrogen phosphoric acid; 2-Amino-3-hydroxyoctadecyl dihydrogen phosphate; Dihydrosphingosine 1-phosphate; Dihydrosphingosine 1-phosphoric acid; Dihydrosphingosine-1-phosphate; Dihydrosphingosine-1-phosphoric acid; Sphinganine 1-phosphoric acid
Source Endogenous;Yeast Metabolite;Sphingolipids;Food;Microbial
Structure Type   Phosphosphingolipids  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Sphingolipids
Phosphosphingolipids
PubChem CID
644260
HMDB ID
HMDB0001383
Formula
C18H40NO5P
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C01120
ChEBI ID
16893
FooDB ID
FDB022594
ChemSpider ID
559277
METLIN ID
3512
Physicochemical Properties Molecular Weight 381.5 Topological Polar Surface Area 113
XlogP 2.4 Complexity 337
Heavy Atom Count 25 Rotatable Bond Count 18
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 6
Function
Sphinganine 1-phosphate is an intermediate in the metabolism of Glycosphingolipids and sphingolipids. It is a substrate for Sphingosine kinase 1, Lipid phosphate phosphohydrolase 2, Sphingosine kinase 2, Sphingosine-1-phosphate lyase 1, Lipid phosphate phosphohydrolase 1 and Lipid phosphate phosphohydrolase 3.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change Sphinganine 1-phosphate concentration: increase (FC = 1.65)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the increase of sphinganine 1-phosphate levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

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