Details of Metabolite

General Information of MET (ID: META00408)
Name D-Erythrose 4-phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2R,3R)-2,3-Dihydroxy-4-(phosphonooxy)butanal; 4-O-Phosphono-D-erythrose; D-Erythrose 4-PO4; D-Erythrose 4-phosphate; D-Erythrose 4-phosphoric acid; D-Erythrose-4-P; D-Erythrose-4-phosphate; Erythose-4-phosphate; Erythose-4-phosphoric acid; Erythrose 4-PO4; Erythrose 4-phosphate; Erythrose 4-phosphate, ((r*,r*)-(+-))-isomer; Erythrose 4-phosphate, (r*,r*)-isomer; Erythrose-4-P; Erythrose-4-phosphate; Erythrose-4P; Threose 4-phosphate
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;TCM Ingredients;Microbial
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
122357
HMDB ID
HMDB0001321
Formula
C4H9O7P
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=122357"></iframe>
3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00279
DrugBank ID
DB03937
ChEBI ID
48153
FooDB ID
FDB001614
ChemSpider ID
109096
METLIN ID
6158
Physicochemical Properties Molecular Weight 200.08 Topological Polar Surface Area 124
XlogP -3.3 Complexity 186
Heavy Atom Count 12 Rotatable Bond Count 5
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 7
Function
D-Erythrose 4-phosphate is a phosphorylated derivative of erythrose that serves as an important intermediate in the pentose phosphate pathway. It is also used in phenylalanine, tyrosine and tryptophan biosynthesis, and it plays a role in vitamin B6 metabolism (KEGG).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change D-Erythrose 4-phosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of D-erythrose 4-phosphate levels compared with control group.
      Pore-forming PNC peptide (PNC)
            Cellular tumor antigen p53 (TP53) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Knockout of TP53
                      Induced Change D-Erythrose 4-phosphate concentration: increase (Log2 FC=1.23)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Colon cancer [ICD-11: 2B90]
                      Details It is reported that knockout of TP53 leads to the increase of D-erythrose 4-phosphate levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.
2 Integrative omics analysis of p53-dependent regulation of metabolism. FEBS Lett. 2018 Feb;592(3):380-393.

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