Details of Metabolite

General Information of MET (ID: META00402)
Name Geranyl-PP
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(2E)-3,7-Dimethylocta-2,6-dien-1-yl trihydrogen diphosphate; Geranyl diphosphate; Geranyl pyrophosphate; Geranyl pyrophosphoric acid; Geranyl-diphosphate; Geranyl-pyrophosphate; Monoterpenyl diphosphate; Neryl diphosphate; P-[(2E)-3,7-Dimethyl-2,6-octadien-1-yl]diphosphoric acid; Polyisopentenyldiphosphate; Polyisopentenyldiphosphoric acid; Polyisopentenylpyrophosphate; Polyisopentenylpyrophosphoric acid; Polyprenyl diphosphate; Polyprenyl diphosphoric acid; trans-Geranyl pyrophosphate; trans-Polyisopentenyldiphosphate; trans-Polyisopentenyldiphosphoric acid; trans-geranyl-PP
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Prenol lipids;Food;Drug;TCM Ingredients;Microbial
Structure Type   Isoprenoid phosphates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Prenol lipids
Isoprenoid phosphates
PubChem CID
445995
HMDB ID
HMDB0001285
Formula
C10H20O7P2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C05847
DrugBank ID
DB02552
ChEBI ID
17211
FooDB ID
FDB001463
ChemSpider ID
393471
METLIN ID
6134
Physicochemical Properties Molecular Weight 314.21 Topological Polar Surface Area 113
XlogP 0.7 Complexity 431
Heavy Atom Count 19 Rotatable Bond Count 8
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7
Function
Geranyl diphosphate is the precursor of monoterpenes, a large family of natural occurring C10 compounds predominately found in plants and animals. Geranyl diphosphate is regarded as a key intermediate in the steroid, isoprene and terpene biosynthesis pathways and is used by organisms in the biosynthesis of farnesyl pyrophosphate, geranylgeranyl pyrophosphate, cholesterol, terpenes and terpenoids. In humans, geranyl diphosphate synthase (GPPS) catalyzes the condensation of dimethylallyl diphosphate (DMAPP) and isopentenyl diphosphate (IPP) to form geranyl diphosphate. Animals produce IPP through the mevalonate (MVA) pathway. Isoprenoid compounds have been implicated in several human disease states including coronary heart disease, blindness, infectious hepatitis and cancer. Geranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway used by organisms in the biosynthesis of terpenes and terpenoids. -- Wikipedia.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change Geranyl-PP concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of geranyl-PP levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.

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