Details of Metabolite

General Information of MET (ID: META00400)
Name dTDP
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2'-Deoxyribosylthymine 5'-(trihydrogen diphosphate), 'Deoxy-TDP', Deoxythymidine 5'-diphosphate, Thymidine 5'-diphosphate, Thymidine 5'-pyrophosphate, THYMIDINE-5'- diphosphATE, 2'-Deoxyribosylthymine 5'-(trihydrogen diphosphoric acid), Deoxythymidine 5'-diphosphoric acid, Thymidine 5'-diphosphoric acid, Thymidine 5'-pyrophosphoric acid, THYMIDINE-5'- diphosphoric acid, 'TDP
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Microbial
Structure Type   Pyrimidine deoxyribonucleotides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Pyrimidine nucleotides
Pyrimidine deoxyribonucleotides
PubChem CID
164628
HMDB ID
HMDB0001274
Formula
C10H16N2O11P2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00363
DrugBank ID
DB03103
ChEBI ID
18075
FooDB ID
FDB022528
ChemSpider ID
144320
METLIN ID
6129
Physicochemical Properties Molecular Weight 402.19 Topological Polar Surface Area 192
XlogP -3.9 Complexity 688
Heavy Atom Count 25 Rotatable Bond Count 6
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 11
Function
Is an intermediate in the Thymidylate kinase (EC 2.7.4.9; ATP:dTMP phosphotransferase) catalyzes the phosphorylation of dTMP (to form dTDP) in the dTTP synthesis pathway for DNA synthesis. (OMIM 188345 )
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Mitochondrial carrier (MC)
            Solute carrier family 25 member 33 (SLC25A33) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Recombinant protein addition of SLC25A33
                      Induced Change dTDP concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that recombinant protein addition of SLC25A33 leads to the increase of dTDP levels compared with control group.
References
1 The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters. J Biol Chem. 2014 Nov 28;289(48):33137-48.

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