Details of Metabolite

General Information of MET (ID: META00396)
Name Dehydroascorbic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Acid, dehydroascorbic; DHAA; Dehydro-L-ascorbate; Dehydro-L-ascorbic acid; Dehydroascorbate; Dehydroascorbic acid; L-Dehydro-ascorbate; L-Dehydroascorbate; L-Dehydroascorbic acid; L-threo-2,3-Hexodiulosonate, g-lactone; L-threo-2,3-Hexodiulosonic acid, gamma-lactone; L-threo-Dehydroascorbic acid; L-threo-hexo-2,3-diulosono-1,4-Lactone; Oxidized ascorbate; Oxidized ascorbic acid; Oxidized vitamin C
Source Endogenous;Escherichia Coli Metabolite;Food
Structure Type   Gamma butyrolactones  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organoheterocyclic compounds
Lactones
Gamma butyrolactones
PubChem CID
440667
HMDB ID
HMDB0001264
Formula
C6H6O6
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C05422
DrugBank ID
DB08830
ChEBI ID
27956
FooDB ID
FDB011907
ChemSpider ID
389547
METLIN ID
342
Physicochemical Properties Molecular Weight 174.11 Topological Polar Surface Area 101
XlogP -1 Complexity 244
Heavy Atom Count 12 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6
Function
Dehydroascorbic acid is the oxidized form of vitamin C. Reduced Vitamin C concentrations in the brain exceed those in blood by 10 fold. Dehydroascorbic acid readily enters the brain and is retained in the brain tissue in the form of ascorbic acid (ascorbic acid is not able to cross the blood-brain barrier). Therefore, transport of dehydroascorbic acid by the Glucose Transporter 1 (GLUT1, Glucose transporters are integral membrane glycoproteins involved in transporting glucose into most cells. GLUT1 is a major glucose transporter in the mammalian blood-brain barrier. It is present at high levels in primate erythrocytes and brain endothelial cells.) is a mechanism by which the brain acquires vitamin C. (OMIM 138140).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Sugar transporter (ST)
            Glucose transporter type 14 (GLUT-14) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Overexpression of SLC2A14
                      Induced Change Dehydroascorbic acid concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Inflammatory bowel disease [ICD-11: DD72]
                      Details It is reported that overexpression of SLC2A14 leads to the increase of dehydroascorbic acid levels compared with control group.
References
1 The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease. Am J Clin Nutr. 2017 Dec;106(6):1508-1513.

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