Details of Metabolite

General Information of MET (ID: META00377)
Name FMNH2
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1,5-Dihydroriboflavin 5'-(dihydrogen phosphate), 'Flavin mononucleotide (reduced); FMNH; Flavin mononucleotide hydroquinone; Reduced FMN', 1,5-Dihydroriboflavin 5'-(dihydrogen phosphoric acid), 'Reduced flavin mononucleotide
Source Aromatic heteropolycyclic compounds
Structure Type   Flavin nucleotides  (Click to Show/Hide the Complete Structure Type Hierarchy)
Nucleosides, nucleotides, and analogues
Flavin nucleotides
PubChem CID
445395
HMDB ID
HMDB0001142
Formula
C17H23N4O9P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C01847
ChEBI ID
16048
FooDB ID
FDB022449
ChemSpider ID
393046
METLIN ID
6034
Physicochemical Properties Molecular Weight 458.4 Topological Polar Surface Area 201
XlogP -2.3 Complexity 803
Heavy Atom Count 31 Rotatable Bond Count 7
Hydrogen Bond Donor Count 8 Hydrogen Bond Acceptor Count 11
Function
FMNH2 is the reduced form of flavin mononucleotide. It is a substrate of the enzyme FMN reductase (EC 1.5.1.29), an enzyme that catalyzes the chemical reaction FMNH2 + NAD(P)+ <=> FMN + NAD(P)H + H+. Flavin mononucleotide (FMN), or riboflavin-5&prime;-phosphate, is a biomolecule produced from riboflavin (vitamin B2) by the enzyme riboflavin kinase and functions as prosthetic group of various oxidoreductases including NADH dehydrogenase. During a catalytic cycle, the reversible interconversion of oxidized (FMN), semiquinone (FMNH&bull;) and reduced (FMNH2) forms occurs in the various oxidoreductases. FMN is a stronger oxidizing agent than NAD and is particularly useful because it can take part in both one- and two-electron transfers.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change FMNH2 concentration: increase (FC = 1.63 / 1.64)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the increase of FMNH2 levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.

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