Details of Metabolite

General Information of MET (ID: META00373)
Name 2-Aminobenzoic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-Amino-2-carboxybenzene; 2-Amino-benzoate; 2-Amino-benzoic acid; 2-Aminobenzoate; 2-Aminobenzoesaeure; 2-Aminophenylacetate; 2-Aminophenylacetic acid; 2-Carboxyaniline; Anthranate; Anthranic acid; Anthranilate; Anthranilic acid; Anthranilic acid GR; Anthranilic acid, cadmium salt; Anthranilic acid, calcium (2:1) salt; Anthranilic acid, dihydrochloride; Anthranilic acid, hydrochloride; Anthranilic acid, monolithium salt; Anthranilic acid, monosodium salt; Carboxyaniline; H-2-Abz-OH; Kyselina O-aminobenzoova; Kyselina anthranilova; O-Amino-benzoate; O-Amino-benzoic acid; O-Aminobenzoate; O-Aminobenzoesaeure; O-Aminobenzoic acid; O-Anthranilate; O-Anthranilic acid; O-Carboxyaniline; Ortho-amidobenzoate; Ortho-amidobenzoic acid; Ortho-aminobenzoate; Ortho-aminobenzoic acid; Sodium anthranilate; Vitamin L; Vitamin L1
Source Food;Escherichia Coli Metabolite;Yeast Metabolite;Food;Carcinogenic Potency;Drug;Toxins/Pollutant;TCM Ingredients;Microbial
Structure Type   Benzoic acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Benzenoids
Benzene and substituted derivatives
Benzoic acids and derivatives
PubChem CID
227
HMDB ID
HMDB0001123
Formula
C7H7NO2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00108
DrugBank ID
DB04166
ChEBI ID
30754
FooDB ID
FDB000896
ChemSpider ID
222
METLIN ID
6018
Physicochemical Properties Molecular Weight 137.14 Topological Polar Surface Area 63.3
XlogP 1.2 Complexity 136
Heavy Atom Count 10 Rotatable Bond Count 1
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Function
2-Aminobenzoic acid is an organic compound. It is a substrate of enzyme anthranilate hydroxylase [EC 1.14.13.35] in benzoate degradation via hydroxylation pathway (KEGG). 2-Aminobenzoic acid has been identified as a uremic toxin according to the European Uremic Toxin Working Group.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change 2-Aminobenzoic acid concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of 2-aminobenzoic acid levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.

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