Details of Metabolite

General Information of MET (ID: META00371)
Name Carbamoyl phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
(Carbamoyloxy)phosphonic acid; Aminocarbonyl dihydrogen phosphate; Aminocarbonyl dihydrogen phosphoric acid; Carbamic acid monoanhydride with phosphorate; Carbamic acid monoanhydride with phosphoric acid; Carbamic phosphoric monoanhydride; Carbamoyl phosphate; Carbamoyl phosphoric acid; Carbamoyl-P; Carbamoyl-phosphate; Carbamoylphosphate; Carbamyl phosphate; Carbamyl phosphoric acid; Carbamyl-phosphate; Monocarbamoyl phosphate; Monocarbamoyl phosphoric acid; Phosphate mono(formamide)ester; Phosphate, carbamoyl; Phosphate, carbamyl; Phosphoric acid mono(formamide)ester
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Microbial
Structure Type   Organic phosphoric acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Organic phosphoric acids and derivatives
PubChem CID
278
HMDB ID
HMDB0001096
Formula
CH4NO5P
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00169
ChEBI ID
17672
FooDB ID
FDB022424
ChemSpider ID
272
METLIN ID
6002
Physicochemical Properties Molecular Weight 141.02 Topological Polar Surface Area 110
XlogP -2.1 Complexity 135
Heavy Atom Count 8 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 5
Function
Carbamoyl phosphate is a precursor of both arginine and pyrimidine biosynthesis. It is a labile and potentially toxic intermediate. Carbamoyl phosphate is a molecule that is involved in ridding the body of excess nitrogen in the urea cycle, and also in the synthesis of pyrimidines. It is produced from carbon dioxide, ammonia, and phosphate (from ATP) by the enzyme carbamoyl phosphate synthase. -- Wikipedia.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change Carbamoyl phosphate concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of carbamoyl phosphate levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.

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