Details of Metabolite

General Information of MET (ID: META00353)
Name dGDP
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2'-Deoxyguanosine 5'-diphosphate, 'Deoxyguanosine diphosphate', 2'-Deoxyguanosine 5'-diphosphoric acid, 'Deoxyguanosine diphosphoric acid', 2'-Deoxy-GDP, 2'-Deoxyguanosine-5'-diphosphate, 5'-dGDP, Deoxyguanosine 5'-diphosphate, 'Deoxyguanosine-diphosphate
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Microbial
Structure Type   Hydroxycinnamic acids and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Phenylpropanoids and polyketides
Cinnamic acids and derivatives
Hydroxycinnamic acids and derivatives
PubChem CID
439220
HMDB ID
HMDB0000960
Formula
C10H15N5O10P2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00361
DrugBank ID
DB03491
ChEBI ID
28862
FooDB ID
FDB022338
ChemSpider ID
388359
METLIN ID
5906
Physicochemical Properties Molecular Weight 427.2011 Topological Polar Surface Area N.A.
XlogP N.A. Complexity N.A.
Heavy Atom Count N.A. Rotatable Bond Count N.A.
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count N.A.
Function
dGDP is a derivative of the common nucleic acid GTP, or guanosine triphosphate, in which the -OH (hydroxyl) group on the 2' carbon on the nucleotide's pentose has been removed (hence the deoxy- part of the name). Additionally, the diphosphate of the name indicates that one of the phosphoryl groups of GTP has been removed, most likely by hydrolysis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Mitochondrial carrier (MC)
            Solute carrier family 25 member 33 (SLC25A33) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Recombinant protein addition of SLC25A33
                      Induced Change dGDP concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that recombinant protein addition of SLC25A33 leads to the increase of dGDP levels compared with control group.
            Solute carrier family 25 member 36 (SLC25A36) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Recombinant protein addition of SLC25A36
                      Induced Change dGDP concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that recombinant protein addition of SLC25A36 leads to the increase of dGDP levels compared with control group.
References
1 The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters. J Biol Chem. 2014 Nov 28;289(48):33137-48.

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