Details of Metabolite

General Information of MET (ID: META00331)
Name Ureidosuccinic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
2-Ureidobutanedioate; 2-Ureidobutanedioic acid; Carbamoylaspartic acid; Carbamyl-DL-aspartate; Carbamyl-L-aspartate; Carbamyl-L-aspartic acid; Carbamylaspartic acid; L-N-Carbamoylaspartic acid; L-Ureidosuccinate; L-Ureidosuccinic acid; N-(Aminocarbonyl)-L-aspartate; N-(Aminocarbonyl)-L-aspartic acid; N-Carbamoyl-D-aspartic acid; N-Carbamoyl-L-aspartate; N-Carbamoyl-L-aspartic acid; N-Carbamoyl-S-aspartate; N-Carbamoyl-S-aspartic acid; N-Carbamoylaspartate; N-Carbamoylaspartic acid; NCD; Ureidosuccinate; Ureidosuccinic acid, (D)-isomer; Ureidosuccinic acid, (L)-isomer; Ureidosuccinic acid, cobalt (+2), (1:1) salt,(L)-isomer; Ureidosuccinic acid, maganeese (+2), (1:1) salt; Ureidosuccinic acid, zinc (1:1) salt, (L)-isomer
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food;Drug;Microbial
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
93072
HMDB ID
HMDB0000828
Formula
C5H8N2O5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00438
DrugBank ID
DB04252
ChEBI ID
15859
FooDB ID
FDB031033
ChemSpider ID
84022
METLIN ID
5791
Physicochemical Properties Molecular Weight 176.13 Topological Polar Surface Area 130
XlogP -1.9 Complexity 214
Heavy Atom Count 12 Rotatable Bond Count 4
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Function
Ureidosuccinic acid is an intermediary product in pyrimidine biosynthesis.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Leukotriene-C4 hydrolase (GGT1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (siRNA) of GGT1
                      Induced Change Ureidosuccinic acid concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Renal cell carcinoma [ICD-11: 2C90]
                      Details It is reported that knockdown of GGT1 leads to the increase of ureidosuccinic acid levels compared with control group.
      Sugar transporter (ST)
            Facilitated glucose transporter 1 (SLC2A1A) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Downregulation of slc2a1a caused by Yap loss-of-function mutation
                      Induced Change Ureidosuccinic acid concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that downregulation of slc2a1a caused by Yap loss-of-function mutation leads to the decrease of ureidosuccinic acid levels compared with control group.
      Transcriptional coactivator (TC)
            Transcriptional coactivator YAP1 (yap1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Decrease of Yap mRNA caused by Yap loss-of-function mutation
                      Induced Change Ureidosuccinic acid concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that decrease of Yap mRNA caused by Yap loss-of-function mutation leads to the decrease of ureidosuccinic acid levels compared with control group.
      Transferases (EC 2)
            Pyridoxal kinase (PDXK) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [3]
                      Introduced Variation Knockout (CRISPR/Cas9 sgRNA) of Pdxk
                      Induced Change Ureidosuccinic acid concentration: decrease
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute myeloid leukaemia [ICD-11: 2A60]
                      Details It is reported that knockout of Pdxk leads to the decrease of ureidosuccinic acid levels compared with control group.
References
1 Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma. Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6274-E6282.
2 Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth. EMBO J. 2018 Nov 15;37(22):e100294.
3 Vitamin B6 Addiction in Acute Myeloid Leukemia. Cancer Cell. 2020 Jan 13;37(1):71-84.e7.

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