Details of Metabolite

General Information of MET (ID: META00320)
Name Hydrocinnamic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
3-Phenyl propionic acid; 3-Phenyl-N-propionate; 3-Phenyl-N-propionic acid; 3-Phenyl-propionate; 3-Phenyl-propionic acid; 3-Phenylpropanoate; 3-Phenylpropanoic acid; 3-Phenylpropionate; 3-Phenylpropionic acid; 3-Phenylpropionic acid, sodium salt; 3-Phenylpropionsaeure; 3PP; Benzenepropanoate; Benzenepropanoic acid; Benzenepropionate; Benzenepropionic acid; Benzylacetate; Benzylacetic acid; Dihydrocinnamate; Dihydrocinnamic acid; HYDROCINNAMIC ACID; Hydrocinnamate; Hydrozimtsaeure; Omega-phenylpropanoate; Omega-phenylpropanoic acid; Phenylpropanoate; Phenylpropanoic acid; Phenylpropionic acid; W-Phenylpropanoate; W-Phenylpropanoic acid; b-Phenylpropionate; b-Phenylpropionic acid; beta-Phenylpropionic acid
Source Endogenous;Drug Metabolite;Escherichia Coli Metabolite;Food;Drug;Food additives;TCM Ingredients;Microbial
Structure Type   Phenylpropanoic acids  (Click to Show/Hide the Complete Structure Type Hierarchy)
Phenylpropanoids and polyketides
Phenylpropanoic acids
PubChem CID
107
HMDB ID
HMDB0000764
Formula
C9H10O2
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C05629
DrugBank ID
DB02024
ChEBI ID
28631
FooDB ID
FDB008271
ChemSpider ID
10181339
METLIN ID
4153
Physicochemical Properties Molecular Weight 150.17 Topological Polar Surface Area 37.3
XlogP 1.8 Complexity 126
Heavy Atom Count 11 Rotatable Bond Count 3
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Function
Hydrocinnamic acid, also known as phenylpropanoic acid, is an analogue of phenylalanine. It is a substrate of the enzyme oxidoreductases (EC 1.14.12.-) in the pathway phenylalanine metabolism (KEGG). Hydrocinnamic acid is a microbial metabolite and it can be found in Clostridium and Eubacterium. It is a marker for the presence of Clostridium sporogenes in the gut. Higher levels are associated with higher levels of Clostridium sporogenes. Hydrocinnamic acid is detected after the consumption of whole grain.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change Hydrocinnamic acid concentration: decrease (FC = 0.49)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of hydrocinnamic acid levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

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