General Information of MET (ID: META00318)
Name Glycylleucine
Synonyms   Click to Show/Hide Synonyms of This Metabolite
G-L; G-L dipeptide; GL; GL dipeptide; Gly-L-leu; Gly-leu; Glycine leucine dipeptide; Glycine-leucine dipeptide; Glycyl-L-leucine; Glycyl-leucine; Glycylleucine; Glycylleucine, (D)-isomer; Leu-gly; Leucylglycine; N-Glycyl-L-leucine; N-Glycylleucine; NSC 83257
Source Endogenous;Food
Structure Type   Amino acids, peptides, and analogues  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic acids and derivatives
Carboxylic acids and derivatives
Amino acids, peptides, and analogues
PubChem CID
92843
HMDB ID
HMDB0000759
Formula
C8H16N2O3
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C02155
ChEBI ID
73514
FooDB ID
FDB022228
ChemSpider ID
83812
METLIN ID
5727
Physicochemical Properties Molecular Weight 188.22 Topological Polar Surface Area 92.4
XlogP -2.3 Complexity 192
Heavy Atom Count 13 Rotatable Bond Count 5
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Function
Glycylleucine is a dipeptide composed of glycine and leucine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. It appears to be a common substrate for glycyl-leucine dipeptidase.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change Glycylleucine concentration: decrease (FC = 0.06 / 0.11)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the decrease of glycylleucine levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.

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