| General Information of MET (ID: META00295) |
| Name |
Ortho-Hydroxyphenylacetic acid
|
| Synonyms |
Click to Show/Hide Synonyms of This Metabolite
(2-Hydroxyphenyl)acetate; (2-Hydroxyphenyl)acetic acid; (O-Hydroxyphenyl)-acetate; (O-Hydroxyphenyl)-acetic acid; (O-Hydroxyphenyl)acetate', 2'-Hydroxyphenylacetate, '2-Hydroxybenzeneacetate; (O-Hydroxyphenyl)acetic acid', 2'-Hydroxyphenylacetic acid, '2-Hydroxybenzeneacetic acid; 2-HPAA; 2-Hydroxyphenylacetate; 2-Hydroxyphenylacetic acid; Hydroxyphenylacetate; Hydroxyphenylacetic acid; O-Hydroxyphenyl acetic acid; O-Hydroxyphenylacetate; O-Hydroxyphenylacetic acid; Ortho-hydroxyphenylacetate; Ortho-hydroxyphenylacetic acid
|
| Source |
Endogenous;Food;Microbial
|
| Structure Type |
Phenylacetic acids (Click to Show/Hide the Complete Structure Type Hierarchy)
Benzenoids
Benzene and substituted derivatives
Phenylacetic acids
|
| PubChem CID |
|
| HMDB ID |
|
| Formula |
C8H8O3
|
| Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=11970"></iframe>
|
 |
|
3D MOL
|
2D MOL
|
|
Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
|
| KEGG ID |
|
| ChEBI ID |
|
| FooDB ID |
|
| ChemSpider ID |
|
| METLIN ID |
|
| Physicochemical Properties |
Molecular Weight |
152.15 |
Topological Polar Surface Area |
57.5 |
| XlogP |
0.9 |
Complexity |
144 |
| Heavy Atom Count |
11 |
Rotatable Bond Count |
2 |
| Hydrogen Bond Donor Count |
2 |
Hydrogen Bond Acceptor Count |
3 |
| Function |
ortho-Hydroxyphenylacetic acid, also known as (o-hydroxyphenyl)acetate or 2-hydroxybenzeneacetic acid, is a member of the class of compounds known as 2(hydroxyphenyl)acetic acids. 2(Hydroxyphenyl)acetic acids are phenylacetic acids that carry a hydroxyl group at the 2-position. ortho-Hydroxyphenylacetic acid is slightly soluble (in water) and a weakly acidic compound (based on its pKa). ortho-Hydroxyphenylacetic acid can be found in a number of food items such as natal plum, lemon verbena, half-highbush blueberry, and parsley, which makes ortho-hydroxyphenylacetic acid a potential biomarker for the consumption of these food products. ortho-Hydroxyphenylacetic acid can be found primarily in blood, feces, and urine. Moreover, ortho-hydroxyphenylacetic acid is found to be associated with phenylketonuria, which is an inborn error of metabolism. ortho-Hydroxyphenylacetic acid is a substrate of the enzyme oxidoreductases (EC 1.14.13.-) in the pathway styrene degradation (KEGG). ortho-Hydroxyphenylacetic acid is also a microbial metabolite.
|
|
Regulatory Network
|
|
|
|
|
|
|
|
|
click to show the details of this protein
Induced Change
