Details of Metabolite

General Information of MET (ID: META00287)
Name Glycine deoxycholate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Acid, glycodeoxycholic; Deoxycholate glycine conjugate; Deoxycholate, glycine; Deoxycholic acid glycine conjugic acid; Deoxycholylglycine; Deoxyglycocholate; Deoxyglycocholic acid; Glycodeoxycholate; Glycodeoxycholic acid; Glycodesoxycholate; Glycodesoxycholic acid; Glycyldeoxycholate; Glycyldeoxycholic acid; N-(3a,12a-Dihydroxy-5b-cholan-24-oyl)-glycine; N-(Carboxymethyl)-3a,12a-dihydroxy-5b-cholan-24-amide
Source Endogenous;Food;Microbial
Structure Type   Bile acids, alcohols and derivatives  (Click to Show/Hide the Complete Structure Type Hierarchy)
Lipids and lipid-like molecules
Steroids and steroid derivatives
Bile acids, alcohols and derivatives
PubChem CID
22833539
HMDB ID
HMDB0000631
Formula
C26H43NO5
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C05464
ChEBI ID
27471
FooDB ID
FDB022152
ChemSpider ID
17215983
METLIN ID
5604
Physicochemical Properties Molecular Weight 449.6 Topological Polar Surface Area 107
XlogP 4.3 Complexity 727
Heavy Atom Count 32 Rotatable Bond Count 6
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 5
Function
Deoxycholic acid glycine conjugate, or Deoxygcholylglycine, is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environment. In hepatocytes, both primary and secondary bile acids undergo amino acid conjugation at the C-24 carboxylic acid on the side chain, and almost all bile acids in the bile duct therefore exist in a glycine conjugated form. As a bile salt it acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and choleretic.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Apolipoprotein (Apo)
            Apolipoprotein A-II (APOA2) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Mutation (-265T >C(rs5082)) of APOA2
                      Induced Change Glycine deoxycholate concentration: decrease (FC = 0.62)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Obesity [ICD-11: 5B81]
                      Details It is reported that mutation (-265T >C(rs5082)) of APOA2 leads to the decrease of glycine deoxycholate levels compared with control group.
References
1 Epigenomics and metabolomics reveal the mechanism of the APOA2-saturated fat intake interaction affecting obesity. Am J Clin Nutr. 2018 Jul 1;108(1):188-200.

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