General Information of MET (ID: META00276)
Name Sodium
Synonyms   Click to Show/Hide Synonyms of This Metabolite
Na(+); Na+; SODIUM ion; Sodium(1+)
Source Food;Escherichia Coli Metabolite;Yeast Metabolite;Food;Microbial
Structure Type   Homogeneous alkali metal compounds  (Click to Show/Hide the Complete Structure Type Hierarchy)
Homogeneous metal compounds
Homogeneous alkali metal compounds
PubChem CID
923
HMDB ID
HMDB0000588
Formula
Na
Structure
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3D MOL is unavailable 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C01330
ChEBI ID
29101
FooDB ID
FDB003523
ChemSpider ID
899
METLIN ID
3192
Physicochemical Properties Molecular Weight 22.989 Topological Polar Surface Area N.A.
XlogP N.A. Complexity N.A.
Heavy Atom Count 1 Rotatable Bond Count N.A.
Hydrogen Bond Donor Count N.A. Hydrogen Bond Acceptor Count N.A.
Function
Sodium ions are necessary for regulation of blood and body fluids, transmission of nerve impulses, heart activity, and certain metabolic functions. Physiologically, it exists as an ion in the body. Sodium is needed by animals, which maintain high concentrations in their blood and extracellular fluids, but the ion is not needed by plants. The human requirement for sodium in the diet is less than 500 mg per day, which is typically less than a tenth as much as many diets "seasoned to taste." Most people consume far more sodium than is physiologically needed. For certain people with salt-sensitive blood pressure, this extra intake may cause a negative effect on health.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Isomerases (EC 5)
            Alpha-methylacyl-CoA racemase (AMACR) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Amacr
                      Induced Change Sodium concentration: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Amacr leads to the increase of sodium levels compared with control group.
References
1 Phytol is lethal for Amacr-deficient mice. Biochim Biophys Acta. 2015 Oct;1851(10):1394-405.

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