Details of Metabolite
Full List of Protein(s) Regulating This Metabolite | ||||||
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GPCR secretin (GPCR-2) | ||||||
Glucagon receptor (GCGR) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[1] | ||||
Introduced Variation | Knockout of Gcgr | |||||
Induced Change | Pyridoxine concentration: increase (FC = 3.6) | |||||
Summary | Introduced Variation
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Disease Status | Type 2 diabetes mellitus [ICD-11: 5A11] | |||||
Details | It is reported that knockout of GCGR leads to the increase of pyridoxine levels compared with control group. | |||||
Pore-forming PNC peptide (PNC) | ||||||
Cellular tumor antigen p53 (TP53) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[2] | ||||
Introduced Variation | Knockout of TP53 | |||||
Induced Change | Pyridoxine concentration: decrease (Log2 FC=0.55) | |||||
Summary | Introduced Variation
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Disease Status | Colon cancer [ICD-11: 2B90] | |||||
Details | It is reported that knockout of TP53 leads to the decrease of pyridoxine levels compared with control group. | |||||
Transcription factor (TF) | ||||||
R2R3-MYB (AN2) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[3] | ||||
Introduced Variation | Overexpression of AN2 | |||||
Induced Change | Pyridoxine concentration: increase (FC = 2.62) | |||||
Summary | Introduced Variation
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Disease Status | Healthy individual | |||||
Details | It is reported that overexpression of AN2 leads to the increase of pyridoxine levels compared with control group. | |||||
Transferases (EC 2) | ||||||
Arylamine N-acetyltransferase 1 (NAT1) | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
Detailed Information |
Protein Info
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Regulating Pair |
Experim Info
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[4] | ||||
Introduced Variation | Knockout of NAT1 | |||||
Induced Change | Pyridoxine concentration: increase (FC = 4.5) | |||||
Summary | Introduced Variation
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Disease Status | Breast cancer [ICD-11: 2C60] | |||||
Details | It is reported that knockout of NAT1 leads to the increase of pyridoxine levels compared with control group. | |||||
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