Details of Metabolite

General Information of MET (ID: META00206)
Name myo-Inositol 1-phosphate
Synonyms   Click to Show/Hide Synonyms of This Metabolite
1-(Dihydrogen phosphate) myo-inositol; 1D-Myo-inositol 1-monophosphate; 1D-Myo-inositol 1-monophosphoric acid; 1D-Myo-inositol 1-phosphoric acid; 1D-myo-Inositol 1-phosphate; D-Myo-inositol 1-phosphate; D-Myo-inositol 1-phosphoric acid; D-myo-Inositol-1-monophosphate; I1P; IPhC; Inositol 1-phosphate; Inositol 1-phosphoric acid; Inositol monophosphate; Inositol phosphate; Inositophosphoric acid; Ins(1)p; Ins1p; Myo-inositol 1-phosphate; Myo-inositol 1-phosphoric acid; Myoinositol 1-phosphate; Myoinositol 1-phosphoric acid; myo-Inositol 1-monophosphate; myo-Inositol-1-phosphate
Source Endogenous;Escherichia Coli Metabolite;Yeast Metabolite;Food
Structure Type   Alcohols and polyols  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Alcohols and polyols
HMDB ID
HMDB0000213
Formula
C6H13O9P
Structure
2D MOL
KEGG ID
C01177
ChEBI ID
18297
FooDB ID
FDB021907
ChemSpider ID
10375592
METLIN ID
5223
Function
myo-Inositol 1-phosphate, also known as I1P or ins(1)p, belongs to the class of organic compounds known as inositol phosphates. Inositol phosphates are compounds containing a phosphate group attached to an inositol (or cyclohexanehexol) moiety. myo-Inositol 1-phosphate is a metabolite of inositol phosphate metabolism and the phosphatidylinositol signalling system. Inositol phosphatases (EC:3.1.3.25) play a crucial role in the phosphatidylinositol signalling pathway. Expression is substantially higher in the subcortical regions of the brain, most prominently in the caudate. The phosphatidylinositol pathway is thought to be modified by lithium, a commonly prescribed medication in treating bipolar disorder (OMIM: 605922).
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Hydrolases (EC 3)
            Sulfatase sulf-1 (SULF1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockdown (shRNA) of SULF1
                      Induced Change myo-Inositol 1-phosphate concentration: decrease (FC = 0.70 / 0.81)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Ovarian cancer [ICD-11: 2C73]
                      Details It is reported that knockdown of SULF1 leads to the decrease of myo-inositol 1-phosphate levels compared with control group.
      Transcription factor (TF)
            Forkhead box protein O1 (FOXO1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [2]
                      Introduced Variation Overexpression of Foxo1
                      Induced Change myo-Inositol 1-phosphate concentration: increase (FC = 1.30)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that overexpression of Foxo1 leads to the increase of myo-inositol 1-phosphate levels compared with control group.
References
1 Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer Metab. 2014 Nov 4;2:24.
2 Metabolomic analysis of C2C12 myoblasts induced by the transcription factor FOXO1. FEBS Lett. 2019 Jun;593(12):1303-1312.

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