Details of Metabolite

General Information of MET (ID: META00169)
Name Glucuronic acid
Synonyms   Click to Show/Hide Synonyms of This Metabolite
D-(+)-Glucuronate; D-(+)-Glucuronic acid; D-Glucopyranuronic acid; D-Glucuronate; GCU; GlcAa; GlcAalpha; Glucosiduronate; Glucosiduronic acid; Glucuronate; Glucuronic acid; alpha-D-Glucopyranuronic acid; alpha-D-Glucuronic acid
Source Endogenous;Drug Metabolite;Drug;Escherichia Coli Metabolite;Food;Plant Metabolite; Microbial
Structure Type   Carbohydrates and carbohydrate conjugates  (Click to Show/Hide the Complete Structure Type Hierarchy)
Organic oxygen compounds
Organooxygen compounds
Carbohydrates and carbohydrate conjugates
PubChem CID
444791
HMDB ID
HMDB0000127
Formula
C6H10O7
Structure
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3D MOL 2D MOL
  Click to Show/Hide the Molecular/Functional Data (External Links/Property/Function) of This Metabolite
KEGG ID
C00191
ChEBI ID
42717
FooDB ID
FDB021897
ChemSpider ID
392615
METLIN ID
161
Physicochemical Properties Molecular Weight 194.14 Topological Polar Surface Area 127
XlogP -2.3 Complexity 205
Heavy Atom Count 13 Rotatable Bond Count 1
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 7
Function
Glucuronic acid (CAS: 6556-12-3) is a carboxylic acid that has the structure of a glucose molecule that has had its sixth carbon atom (of six total) oxidized. The salts of glucuronic acid are known as glucuronates. Glucuronic acid is highly soluble in water. In humans, glucuronic acid is often linked to toxic or poisonous substances to allow for subsequent elimination, and to hormones to allow for easier transport. These linkages involve O-glycosidic bonds. The process is known as glucuronidation, and the resulting substances are known as glucuronides (or glucuronosides). Glucuronidation uses UDP-glucuronic acid (glucuronic acid linked via a glycosidic bond to uridine diphosphate) as an intermediate. UDP-glucuronic acid is formed in the liver of all animals.
Regulatory Network
Full List of Protein(s) Regulating This Metabolite
      Nucleobase/ascorbate transporter (NAT)
            Solute carrier family 23 member 1 (SLC23A1) Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Protein   Info click to show the details of this protein
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Knockout of Slc23a1
                      Induced Change Glucuronic acid concentration: increase (FC = 2)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that knockout of Slc23a1 leads to the increase of glucuronic acid levels compared with control group.
References
1 Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. J Clin Invest. 2010 Apr;120(4):1069-83.

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