Details of Protein

General Information of Protein (ID: PRT01661)
Name Hemoglobin beta (HBB)
Synonyms   Click to Show/Hide Synonyms of This Protein
Beta-globin; Hemoglobin beta chain; HBB
Gene Name HBB Gene ID
3043
UniProt ID
P68871
Family Pore-forming globin (PFG)
TC Number   TC: 1.A.107.1.2  (Click to Show/Hide the Complete TC Tree)
The Pore-forming Globin Family
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TC: 1.A.107.1.2
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPK
VKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFG
KEFTPPVQAAYQKVVAGVANALAHKYH
Structure
1A00 ; 1A01 ; 1A0U ; 1A0Z ; 1A3N ; 1A3O ; 1ABW ; 1ABY ; 1AJ9 ; 1B86 ; 1BAB ; 1BBB ; 1BIJ ; 1BUW ; 1BZ0 ; 1BZ1 ; 1BZZ ; 1C7B ; 1C7C ; 1C7D ; 1CBL ; 1CBM ; 1CH4 ; 1CLS ; 1CMY ; 1COH ; 1DKE ; 1DXT ; 1DXU ; 1DXV ; 1FN3 ; 1G9V ; 1GBU ; 1GBV ; 1GLI ; 1GZX ; 1HAB ; 1HAC ; 1HBA ; 1HBB ; 1HBS ; 1HCO ; 1HDB ; 1HGA ; 1HGB ; 1HGC ; 1HHO ; 1IRD ; 1J3Y ; 1J3Z ; 1J40 ; 1J41 ; 1J7S ; 1J7W ; 1J7Y ; 1JY7 ; 1K0Y ; 1K1K ; 1KD2 ; 1LFL ; 1LFQ ; 1LFT ; 1LFV ; 1LFY ; 1LFZ ; 1LJW ; 1M9P ; 1MKO ; 1NEJ ; 1NIH ; 1NQP ; 1O1I ; 1O1J ; 1O1K ; 1O1L ; 1O1M ; 1O1N ; 1O1O ; 1O1P ; 1QI8 ; 1QSH ; 1QSI ; 1QXD ; 1QXE ; 1R1X ; 1R1Y ; 1RPS ; 1RQ3 ; 1RQ4 ; 1RQA ; 1RVW ; 1SDK ; 1SDL ; 1THB ; 1UIW ; 1VWT ; 1XXT ; 1XY0 ; 1XYE ; 1XZ2 ; 1XZ4 ; 1XZ5 ; 1XZ7 ; 1XZU ; 1XZV ; 1Y09 ; 1Y0A ; 1Y0C ; 1Y0D ; 1Y0T ; 1Y0W ; 1Y22 ; 1Y2Z ; 1Y31 ; 1Y35 ; 1Y45 ; 1Y46 ; 1Y4B ; 1Y4F ; 1Y4G ; 1Y4P ; 1Y4Q ; 1Y4R ; 1Y4V ; 1Y5F ; 1Y5J ; 1Y5K ; 1Y7C ; 1Y7D ; 1Y7G ; 1Y7Z ; 1Y83 ; 1Y85 ; 1Y8W ; 1YDZ ; 1YE0 ; 1YE1 ; 1YE2 ; 1YEN ; 1YEO ; 1YEQ ; 1YEU ; 1YEV ; 1YFF ; 1YG5 ; 1YGD ; 1YGF ; 1YH9 ; 1YHE ; 1YHR ; 1YIE ; 1YIH ; 1YVQ ; 1YVT ; 1YZI ; 2D5Z ; 2D60 ; 2DN1 ; 2DN2 ; 2DN3 ; 2DXM ; 2H35 ; 2HBC ; 2HBD ; 2HBE ; 2HBF ; 2HBS ; 2HCO ; 2HHB ; 2HHD ; 2HHE ; 2M6Z ; 2W6V ; 2W72 ; 2YRS ; 3B75 ; 3D17 ; 3D7O ; 3DUT ; 3HHB ; 3HXN ; 3IC0 ; 3IC2 ; 3KMF ; 3NL7 ; 3NMM ; 3ODQ ; 3ONZ ; 3OO4 ; 3OO5 ; 3P5Q ; 3QJB ; 3QJC ; 3QJD ; 3QJE ; 3R5I ; 3S65 ; 3S66 ; 3SZK ; 3W4U ; 3WCP ; 3WHM ; 4FC3 ; 4HHB ; 4IJ2 ; 4L7Y ; 4M4A ; 4M4B ; 4MQC ; 4MQG ; 4MQH ; 4MQI ; 4N7N ; 4N7O ; 4N7P ; 4N8T ; 4NI0 ; 4NI1 ; 4ROL ; 4ROM ; 4WJG ; 4X0L ; 4XS0 ; 5E29 ; 5E6E ; 5E83 ; 5EE4 ; 5HU6 ; 5HY8 ; 5JDO ; 5KDQ ; 5KSI ; 5KSJ ; 5NI1 ; 5SW7 ; 5U3I ; 5UCU ; 5UFJ ; 5URC ; 5VMM ; 5WOG ; 5WOH ; 5X2R ; 5X2S ; 5X2T ; 5X2U ; 6BB5 ; 6BNR ; 6BWP ; 6BWU ; 6DI4 ; 6FQF ; 6HAL ; 6HBW ; 6HK2 ; 6KA9 ; 6KAE ; 6KAH ; 6KAI ; 6KAO ; 6KAP ; 6KAQ ; 6KAR ; 6KAS ; 6KAT ; 6KAU ; 6KAV ; 6KYE ; 6L5V ; 6L5W ; 6L5X ; 6L5Y ; 6LCW ; 6LCX ; 6NBC ; 6NBD ; 6NQ5 ; 6TB2 ; 6XD9 ; 6XDT ; 6XE7 ; 7JJQ ; 7JXZ ; 7JY0 ; 7JY1 ; 7JY3
Function Involved in oxygen transport from the lung to the various peripheral tissues.; LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure.; [Spinorphin]: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Glutamine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glutamine absence (16 hours)
                      Induced Change HBB protein abundance levels: increase (FC = 4.89)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hepatocellular carcinoma [ICD-11: 2C12]
                      Details It is reported that glutamine absence causes the increase of HBB protein abundance compared with control group.
References
1 Quantitative proteomics analysis reveals glutamine deprivation activates fatty acid -oxidation pathway in HepG2 cells. Amino Acids. 2016 May;48(5):1297-307.

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