Details of Protein

General Information of Protein (ID: PRT01646)
Name Transducin beta chain 1 (GNB1)
Synonyms   Click to Show/Hide Synonyms of This Protein
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; GNB1
Gene Name GNB1 Gene ID
2782
UniProt ID
P62873
Family G-protein alpha/beta/gamma complex (GPC)
TC Number   TC: 8.A.92.1.1  (Click to Show/Hide the Complete TC Tree)
The G-Protein alphabetagamma Complex (GPC) Family
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TC: 8.A.92.1.1
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Structure
4KFM ; 4PNK ; 5HE0 ; 5HE1 ; 5HE2 ; 5HE3 ; 5UKK ; 5UKL ; 5UKM ; 5UZ7 ; 6B3J ; 6CRK ; 6D9H ; 6DDE ; 6DDF ; 6E3Y ; 6EG8 ; 6G79 ; 6GDG ; 6KPF ; 6KPG ; 6LFM ; 6LFO ; 6LI3 ; 6LMK ; 6LML ; 6M1H ; 6M1I ; 6M8S ; 6N4B ; 6NI3 ; 6NIY ; 6OIJ ; 6OIK ; 6OMM ; 6ORV ; 6OS9 ; 6OSA ; 6OT0 ; 6P9X ; 6P9Y ; 6PB0 ; 6PB1 ; 6PT0 ; 6UUN ; 6UUS ; 6UVA ; 6VCB ; 6VMS ; 6VN7 ; 6WHA ; 6WHC ; 6WI9 ; 6WPW ; 6WZG ; 6X18 ; 6X19 ; 6X1A ; 6XBJ ; 6XBK ; 6XBL ; 6XBM ; 6XOX ; 7C2E ; 7CFM ; 7CFN ; 7D7M ; 7K7L ; 7K7Z ; 7L0P ; 7L0Q ; 7L0R ; 7L0S
Function Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Glutamine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glutamine absence (16 hours)
                      Induced Change GNB1 protein abundance levels: increase (FC = 1.40)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hepatocellular carcinoma [ICD-11: 2C12]
                      Details It is reported that glutamine absence causes the increase of GNB1 protein abundance compared with control group.
References
1 Quantitative proteomics analysis reveals glutamine deprivation activates fatty acid -oxidation pathway in HepG2 cells. Amino Acids. 2016 May;48(5):1297-307.

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