Details of Protein
| General Information of Protein (ID: PRT01641) | |||||
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| Name | Cardiac myosin (MYBPC3) | ||||
| Synonyms |
Click to Show/Hide Synonyms of This Protein
Cardiac MyBP-C; C-protein, cardiac muscle isoform; Mybpc3
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| Gene Name | Mybpc3 | Gene ID | |||
| UniProt ID | |||||
| Family | Immunoglobulin (IMG) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein | |||||
| Sequence |
MPEPGKRPVSAFTKKPRSVEVTAGSAAVFEAETERSGLKVQWQRDGSDIAANDKYGLAAE
GKRHTLTVRDVGPDDQGSYAVIAGSSKVKFDLKVTEPAPPEKAESAVAPTSMEAPETPKE VPALATQLEGNVSSPEGSVSVTQDGSVAGSQGAPDDPIGLFLMRPQDGEVTVGGSIVFSA RVAGASLLKPPVVKWFKGKWVDLSSKVGQHLQLHDSYDRASKVYLFELHITDAQATSAGG YRCEVSTKDKFDSCNFNLTVHEAIGSGDLDLRSAFRRTSLAGTGRRTSDSHEDAGTLDFS SLLKKSSFRRDSKLEAPAEEDVWEILRQAPPSEYERIAFQHGVTDLRGMLKRLKGMKHDE KKSTAFQKKLEPAYQVNKGHKIRLTVELADPDAEVKWLKNGQEIQMSGRYIFESIGAKRT LTISQCSLADDAAYQCVVGGEKCSTELFVKEPPVLITRSLEDQLVMVGQRVEFECEVSEE GAQVKWLKDGVELTREETFKYRFKKDGRKHHLIINEATLEDAGHYAVRTSGGQALAELIV QEKKLEVYQSIADLAVGAKDQAVFKCEVSDENVRGVWLKNGKELVPDNRIKVSHIGRVHK LTIDDVTPADEADYSFVPEGFACNLSAKLHFMEVKIDFVPRQEPPKIHLDCPGSTPDTIV VVAGNKLRLDVPISGDPAPTVIWQKTITQGKKASAGPPPGAPEDAGADEEWVFDKKLLCE TEGRVRVETTKDRSVFTVEGAEKEDEGVYTVTVKNPVGEDQVNLTVKVIDVPDAPAAPKI SNVGEDSCIVQWEPPAYDGGQPVLGYILERKKKKSYRWMRLNFDLLRELSHEARRMIEGV AYEMRVYAVNAVGMSRPSPASQPFMPIGPPGEPTHLTVEDVSDTTVSLKWRPPERVGAGG LDGYSVEYCQEGCSEWVTALQGLTERTSLLVKDLPTGARLLFRVRAHNVAGPGGPIITKE PVTVQEILQRPRLQLPRHLRQTIQKKVGEPVNLLIPFQGKPRPQVTWTKEGQPLAGEEVS IRNSPTDTILFIRAAHRTHSGTYQVTVRIENMEDKATLVLQIVDKPSPPLDIRVVETWGF SVALEWKPPQDDGNTEIWGYTVQKADKKTMEWFTVLEHYRQTHCVVSELIIGNGYYFRVF SHNMVGSSDRAAATKEPIFIPRPGITYEPPKYKALDFSEAPSFTQPLTNRSIIAGYNAIL CCAVRGSPKPKISWFKNGLDLGEDARFRMFCKQGVLTLEIRKPCPYDGGVYVCRATNLQG EAQCECRLEVRVPQ |
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| Function | Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. | ||||
| Regulatory Network | |||||
| Full List of Metabolite(s) Regulating This Protein | ||||||
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| Organic acids and derivatives | ||||||
| Citrulline | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
| Detailed Information |
Metabo Info
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| Regulating Pair |
Experim Info
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[1] | ||||
| Introduced Variation | Citrulline addition (1336 hours) | |||||
| Induced Change | MYBPC3 protein expression levels: decrease | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Healthy individual | |||||
| Details | It is reported that citrulline addition causes the decrease of MYBPC3 protein expression compared with control group. | |||||
| References | |||||
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| 1 | Citrulline Supplementation Induces Changes in Body Composition and Limits Age-Related Metabolic Changes in Healthy Male Rats. J Nutr. 2015 Jul;145(7):1429-37. | ||||
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