Details of Protein

General Information of Protein (ID: PRT01619)
Name Peptidyl-prolyl cis-trans isomerase 3 (PPIL3)
Synonyms   Click to Show/Hide Synonyms of This Protein
PPIase; CYP10L; Cyclophilin-like protein PPIL3; Rotamase PPIL3; Ppil3; Cyp10l
Gene Name Ppil3 Gene ID
70225
UniProt ID
Q9D6L8
Family Isomerases (EC 5)
EC Number   EC: 5.2.1.8  (Click to Show/Hide the Complete EC Tree)
Isomerase
Cis-trans-isomerase
Cis-trans isomerase
EC: 5.2.1.8
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MSVTLHTDVGDIKIEVFCERTPKTCENFLALCASNYYNGCVFHRNIKGFMVQTGDPTGTG
RGGSSIWAKKFEDEYSEYLKHNVRGVVSMANNGPNTNGSQFFITYGKQPHLDMKYTVFGK
VIDGLETLDELEKLPVNEKTYRPLNDVHIKDITIHANPFAQ
Function PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Methionine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Methionine decrease (504 hours)
                      Induced Change PPIL3 protein expression levels: decrease (FC = 3.50)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Fatty liver disease [ICD-11: DB92]
                      Details It is reported that methionine decrease causes the decrease of PPIL3 protein expression compared with control group.
References
1 Proteomic analysis of mice fed methionine and choline deficient diet reveals marker proteins associated with steatohepatitis. PLoS One. 2015 Apr 7;10(4):e0120577.

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