Details of Protein

General Information of Protein (ID: PRT01575)
Name Nicotinate-nucleotide pyrophosphorylase (QPRT)
Synonyms   Click to Show/Hide Synonyms of This Protein
Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase; QPRT
Gene Name QPRT Gene ID
23475
UniProt ID
Q15274
Family Transferases (EC 2)
EC Number   EC: 2.4.2.19  (Click to Show/Hide the Complete EC Tree)
Transferase
Glycosyltransferase
Pentosyltransferase
EC: 2.4.2.19
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGVLAGQPFF
DAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAA
AVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGG
VEKAVRAARQAADFTLKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQF
PSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH
Structure
2JBM ; 4KWV ; 4KWW ; 5AYX ; 5AYY ; 5AYZ
Function Involved in the catabolism of quinolinic acid (QA).
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Glutamine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glutamine absence (16 hours)
                      Induced Change QPRT protein abundance levels: increase (FC = 1.37)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hepatocellular carcinoma [ICD-11: 2C12]
                      Details It is reported that glutamine absence causes the increase of QPRT protein abundance compared with control group.
References
1 Quantitative proteomics analysis reveals glutamine deprivation activates fatty acid -oxidation pathway in HepG2 cells. Amino Acids. 2016 May;48(5):1297-307.

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