Details of Protein

General Information of Protein (ID: PRT01571)
Name RING finger protein 181 (RNF181)
Synonyms   Click to Show/Hide Synonyms of This Protein
E3 ubiquitin-protein ligase RNF181; RING-type E3 ubiquitin transferase RNF181; Rnf181
Gene Name Rnf181 Gene ID
66510
UniProt ID
Q9CY62
Family Transferases (EC 2)
EC Number   EC: 2.3.2.27  (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Aminoacyltransferase
EC: 2.3.2.27
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MASYFDEHDCEPLNPEREARNNMLLELARRVRGAWSWAPGGRSLFNRMDFEDLGLVDWEH
HLPPPAAKAVVESLPRTVISSAKADLKCPVCLLEFEAEETVIEMPCHHLFHSNCILPWLS
KTNSCPLCRHELPTDDDSYEEHKKDKARRQQQQHRLENLHGAMYT
Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic oxygen compounds
            Glucose Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glucose (low concentration) addition (17.50 hours)
                      Induced Change RNF181 protein abundance levels: increase (FC = 3.72)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Cerebral stroke [ICD-11: 8B11]
                      Details It is reported that low glucose addition causes the increase of RNF181 protein abundance compared with control group.
References
1 Quantitative Proteomics Reveals the Beneficial Effects of Low Glucose on Neuronal Cell Survival in an in vitro Ischemic Penumbral Model. Front Cell Neurosci. 2020 Sep 1;14:272.

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