Details of Protein

General Information of Protein (ID: PRT01567)
Name Glycine acetyltransferase (KBL)
Synonyms   Click to Show/Hide Synonyms of This Protein
AKB ligase; 2-amino-3-ketobutyrate coenzyme A ligase; b3617; JW3592; kbl
Gene Name kbl Gene ID
58459851
UniProt ID
P0AB77
Family Transferases (EC 2)
EC Number   EC: 2.3.1.29  (Click to Show/Hide the Complete EC Tree)
Transferase
Acyltransferase
Acyltransferase
EC: 2.3.1.29
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MRGEFYQQLTNDLETARAEGLFKEERIITSAQQADITVADGSHVINFCANNYLGLANHPD
LIAAAKAGMDSHGFGMASVRFICGTQDSHKELEQKLAAFLGMEDAILYSSCFDANGGLFE
TLLGAEDAIISDALNHASIIDGVRLCKAKRYRYANNDMQELEARLKEAREAGARHVLIAT
DGVFSMDGVIANLKGVCDLADKYDALVMVDDSHAVGFVGENGRGSHEYCDVMGRVDIITG
TLGKALGGASGGYTAARKEVVEWLRQRSRPYLFSNSLAPAIVAASIKVLEMVEAGSELRD
RLWANARQFREQMSAAGFTLAGADHAIIPVMLGDAVVAQKFARELQKEGIYVTGFFYPVV
PKGQARIRTQMSAAHTPEQITRAVEAFTRIGKQLGVIA
Structure
1FC4
Function Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Glycine Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glycine addition (0.5 hour)
                      Induced Change KBL protein expression levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute infection [ICD-11: 1D00]
                      Details It is reported that glycine addition causes the increase of KBL protein expression compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glycine addition (0.5 hour)
                      Induced Change KBL mRNA levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute infection [ICD-11: 1D00]
                      Details It is reported that glycine addition causes the increase of KBL mRNA levels compared with control group.
            Serine Click to Show/Hide the Full List of Regulating Pair(s):   2 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair (1) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Serine addition (0.5 hour)
                      Induced Change KBL protein expression levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute infection [ICD-11: 1D00]
                      Details It is reported that serine addition causes the increase of KBL protein expression compared with control group.
               Regulating Pair (2) Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Serine addition (0.5 hour)
                      Induced Change KBL mRNA levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Acute infection [ICD-11: 1D00]
                      Details It is reported that serine addition causes the increase of KBL mRNA levels compared with control group.
References
1 Glycine, serine and threonine metabolism confounds efficacy of complement-mediated killing. Nat Commun. 2019 Jul 25;10(1):3325.

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