Details of Protein

General Information of Protein (ID: PRT01563)
Name Dimeric dihydrodiol dehydrogenase (DHDH)
Synonyms   Click to Show/Hide Synonyms of This Protein
D-xylose 1-dehydrogenase; D-xylose-NADP dehydrogenase; Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Dhdh
Gene Name Dhdh Gene ID
71755
UniProt ID
Q9DBB8
Family Oxidoreductases (EC 1)
EC Number   EC: 1.3.1.20  (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-CH donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.3.1.20
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MALRWGIVSAGLIANDFTTVLSSLPSSEHQVVAVAARDLNRAEEFAQKFNIPKAYGSYEE
LAKDPNVEVAYIATQHPQHKPAVLLCLAAGKAVLCEKPMGVNAAEVREMVAKARSQGVFL
MEAIWSRFFPAMEALREVLVQGTIGDLRVARAEFGFDLSHIPRATDWNQAGGGLLDLGIY
CVQFLSMIFGAQKPEKISAVGRIHETGVDDTVSVLLQYPGGVHGSFTCSISSNLPNTAYV
SGTKGMAQIQKLWAPTELVVNGERKEFPPPVLGKDYNFVNGSCMLYEANHVRECLRKGLK
ESPVVPLAESELLAEILEEARKAIGVTFPQDKR
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Methionine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Methionine decrease (504 hours)
                      Induced Change DHDH protein expression levels: decrease (FC = 0.60)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Fatty liver disease [ICD-11: DB92]
                      Details It is reported that methionine decrease causes the decrease of DHDH protein expression compared with control group.
References
1 Proteomic analysis of mice fed methionine and choline deficient diet reveals marker proteins associated with steatohepatitis. PLoS One. 2015 Apr 7;10(4):e0120577.

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