Details of Protein

General Information of Protein (ID: PRT01390)
Name ADP-forming succinate--CoA ligase beta (SUCC)
Synonyms   Click to Show/Hide Synonyms of This Protein
Succinyl-CoA synthetase subunit beta; Succinate--CoA ligase [ADP-forming] subunit beta
Gene Name sucC Gene ID
58256637
UniProt ID
D0ZC78
Family Ligases (EC 6)
EC Number   EC: 6.2.1.5  (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-sulfur ligase
Acid-thiol ligase
EC: 6.2.1.5
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MNLHEYQAKQLFARYGLPTPVGYACSTPRQAEEAASKIGSGPWVVKCQVHAGGRGKAGGV
KCVESKEAIRAFAEQWLGKRLVTYQTDAQGQPVRQILVEGATEIARELYLGAVIDRSSRR
VVFMASTEGGVEIEQVAQKTPHLIHRVALDPLTGPQPYQGRELAFKLGLSGKQAQQFGQI
FMGLATLFLQCDLTMAEINPLVITPQGDLLCLDGKLDVDSNALFRQPALREMEDPEQNDA
REAHAAQWELNYVALEGNIGCMVNGAGLAMGTMDIVKLHGGAPANFLDVGGGATKERVTE
AFKIILSDEHVRAVLVNIFGGIVRCDLIADGIIGAVAEVGVHVPVVVRLEGNNAELGTRI
LADSGLNIIAATSLTDAARQVVSAVEGK
Function Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Alanine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Alanine addition (24 hours)
                      Induced Change SUCC protein abundance levels: increase (FC = 7.02)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that alanine addition causes the increase of SUCC protein abundance compared with control group.
References
1 Alanine Enhances Aminoglycosides-Induced ROS Production as Revealed by Proteomic Analysis. Front Microbiol. 2018 Jan 30;9:29.

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