Details of Protein

General Information of Protein (ID: PRT01381)
Name Diaminopimelate decarboxylase (LYSA)
Gene Name lysA Gene ID
.
UniProt ID
D0ZDW5
Family Lyases (EC 4)
EC Number   EC: 4.1.1.20  (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Carboxy-lyase
EC: 4.1.1.20
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MLIFPEPFAMPYPLNQAGYALNDSLLAALPGRFGTPLWVYDAALIERQIASLRAFDTIRF
AQKACSNLHILRLMRQAGVKVDAVSLGEIERALVAGFRPGGDDEEIVFTADVIDEATLDR
ICALGITVNAGSCDMLRQLGRRASGHPVWLRINPGFGHGHSQKTNTGGENSKHGIWHQDL
AQALALIDTYGLRLVGLHMHIGSGVDYDHLARVCDTLANQAIALGRDIQAISAGGGLSIP
YRDGDAAVDVRHYYGLWDAARRRIAAHLGHPVRLEIEPGRYLVAQAGVLLAQVRAVKSMG
QRHFVLADAGFNDLMRPAMYGSHHHISLLPQDGRDVATPCIETVVGGPLCESGDVFTQRE
GGKVTSCALPAAQVGDWLVFHDTGAYGASMSSNYNSRPLLPEVLVEGNKARLIRRRQRMD
ELLALEQI
Function Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Alanine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Alanine addition (24 hours)
                      Induced Change LYSA protein abundance levels: decrease (FC = 0.44)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that alanine addition causes the decrease of LYSA protein abundance compared with control group.
References
1 Alanine Enhances Aminoglycosides-Induced ROS Production as Revealed by Proteomic Analysis. Front Microbiol. 2018 Jan 30;9:29.

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