Details of Protein

General Information of Protein (ID: PRT01377)
Name Cysteine desulfurase IscS (NIFS)
Gene Name nifS Gene ID
58257954
UniProt ID
D0ZD86
Family Transferases (EC 2)
EC Number   EC: 2.8.1.7  (Click to Show/Hide the Complete EC Tree)
Transferase
Sulfotransferase
Sulfurtransferase
EC: 2.8.1.7
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MKLPIYMDYSATTPADPRVAEKMMQYLTLDGTFGNPASRSHRFGWQAEEAVDVARNNIAE
LVGADPREIVFTSGATEADNLAIKGAANFYQKKGKHIITCKTEHKAVLDTCRQLEREGFE
VTYMAPQPNGLIDLKALEAAMRDDTILVSIMHVNNEIGIIQDIETIGEMCRARGIIFHVD
ATQSVGKLPIDLSKLKVDLMSFSGHKIYGPKGIGALYVRRKPRVRIEAQMHGGGHERGMR
SGTLPVHQIVGMGEAYRIAKEEMPTEVPRLRALRDRLWNGLKDIEEVYLNGSLEQGAPNI
LNVSFNFVEGESLIMALKDLAVSSGSACTSASLEPSYVLRALGLNDELAHSSIRFSLGRF
TTEEEVDYAIDLVRKSIGRLRELSPLWEMHKQGVDLSTIEWSAH
Function Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Alanine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Alanine addition (24 hours)
                      Induced Change NIFS protein abundance levels: increase (FC = 2.14)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that alanine addition causes the increase of NIFS protein abundance compared with control group.
References
1 Alanine Enhances Aminoglycosides-Induced ROS Production as Revealed by Proteomic Analysis. Front Microbiol. 2018 Jan 30;9:29.

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