Details of Protein
| General Information of Protein (ID: PRT01376) | |||||
|---|---|---|---|---|---|
| Name | DNA polymerase III gamma/tau (DNAX) | ||||
| Gene Name | dnaX | Gene ID | |||
| UniProt ID | |||||
| Family | Transferases (EC 2) | ||||
| EC Number | EC: 2.7.7.7 (Click to Show/Hide the Complete EC Tree) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein | |||||
| Sequence |
MIGAGGRQCSPRAISLTPLAVCGTVGESSYSISDESSMSYQVLARKWRPQTFADVVGQEH
VLTALANGLSLGRIHHAYLFSGTRGVGKTSIARLLAKGLNCETGITATPCGVCDNCREIE QGRFVDLLEIDAASRTKVEDTRDLLDNVQYAPARGRFKVYLIDEVHMLSRHSFNALLKTL EEPPPHVKFLLATTDPQKLPVTILSRCLQFHLRALDHEQIRAQLEKIAHAEALTAEPRAL QLLARAAEGSMRDALSLTDQAIAMGQGQITADAVSQMLGTLDDEQPLALIEALTAADGTL VMARVEQAAGRGVDWENLLVEMLALLHRVAMLQLLPSALDSQFAAVEPRLRELARMLPPA DLQLFYQILLNGRKELAFAPDRRMGVEMTLLRALAFHPKAVIAEPSPAPSAAQGGDIPAV PATVAQRVAPPSPATVPPTVSAPPQAASAVPESTAQLLQARSRLRQKAAGGSEPKKSEPA APQRAQPASSALERLASISERGQQKIASAEQEQASTRKEAYRWKAQNRPVEEKAPKTTPK ALRSALEHEKTPELAAHLAQESLTRDAWAQELSQLRLPKLVQQLALNAFREPAPEGSVLL HLRSAQRHLNSASARQTLEQALSDHYGHPVALSIVEDDDPQRRTPLEWRQAIYEERLAQA RASIAADGNIQTLRRLFDAELDEESIRPV |
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| Function | DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | ||||
| Regulatory Network | |||||
| Full List of Metabolite(s) Regulating This Protein | ||||||
|---|---|---|---|---|---|---|
| Organic acids and derivatives | ||||||
| Alanine | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
| Detailed Information |
Metabo Info
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| Regulating Pair |
Experim Info
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[1] | ||||
| Introduced Variation | Alanine addition (24 hours) | |||||
| Induced Change | DNAX protein abundance levels: decrease (FC = 0.39) | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Healthy individual | |||||
| Details | It is reported that alanine addition causes the decrease of DNAX protein abundance compared with control group. | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Alanine Enhances Aminoglycosides-Induced ROS Production as Revealed by Proteomic Analysis. Front Microbiol. 2018 Jan 30;9:29. | ||||
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