Details of Protein

General Information of Protein (ID: PRT01359)
Name HMB-PP synthase (ISPG)
Synonyms   Click to Show/Hide Synonyms of This Protein
4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin); 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Gene Name ispG Gene ID
58257941
UniProt ID
D0ZD73
Family Oxidoreductases (EC 1)
EC Number   EC: 1.17.7.3  (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH/CH2 oxidoreductase
Iron-sulfur protein oxidoreductase
EC: 1.17.7.3
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MHSASPIKRRKSTRIHVGSVPIGDGAPIAVQSMTNTRTTDVDATVAQIRALERVGVDIVR
VSVPTMEAAEAFRLIKQQAQVPLVADIHFDYRIALKVAEYGVDCLRINPGNIGNESRIRS
VVDCARDRGIPIRIGVNAGSLEKDIQEKYGEPTPQALLESAMRHVDILDRLNFDQFKVSV
KASDVFLAVDAYRLLAARIDQPLHLGITEAGGARSGSVKSAIGLGMLLAEGIGDTLRVSL
AADPVEEVKVGFDILKSLRIRSRGINFIACPTCSRQEFDVIGTVNALEQRLEDIITPMDV
SIIGCVVNGPGEALVSTLGVTGGHNKSGFYEDGVRQKERFDNDAIIDLLEAKIRAKAAML
DEKMRIGVTTLDDR
Function Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Alanine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Alanine addition (24 hours)
                      Induced Change ISPG protein abundance levels: increase (FC = 4.2)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that alanine addition causes the increase of ISPG protein abundance compared with control group.
References
1 Alanine Enhances Aminoglycosides-Induced ROS Production as Revealed by Proteomic Analysis. Front Microbiol. 2018 Jan 30;9:29.

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