Details of Protein
| General Information of Protein (ID: PRT01324) | |||||
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| Name | SREBP transcription factor 2 (SREBF2) | ||||
| Synonyms |
Click to Show/Hide Synonyms of This Protein
SREBP-2; Sterol regulatory element-binding transcription factor 2; Srebf2
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| Gene Name | Srebf2 | Gene ID | |||
| UniProt ID | |||||
| Family | Transcription factor (TF) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein | |||||
| Sequence |
MDENSELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFSDLFSEQLCSSFPGGGGG
SGSGGTSNNSSGRGTSGGAADPAVQRSFSQVPLSTFSPSSTSPQAPALQVKVSPTPPRAT PVLQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTRIIQQPLIYQNAATSFQVLQPQVQSL VTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVATPQVQQVPVLVQPQII KTDSLVLTTLKTDGSPVMAAVQNPALTALTAPIQTAALQVPTLVGSNGAILTTMPVMMGQ EKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSG VLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDSDVDLKIDDFNQNV LLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLT FLGLSFNPLTSLLQWGGAHNPDQHPYSGSGRNVLSLESGSGGWFDWMMPTLLLWLLNGVI VLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLAKGDFAAAAANLQTCLSVLGRAL PTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQRWRATPATAAGFEDEAKSSARDAAL AYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRC GGKLGFLASYFLNRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSIKSAAKDSLYCA QRNPADPIAQVHQAFCKHLLERAVEALVKPQAKKKAGDREEESCEFSSALEFLKLLHSFV DSVGFVASPFSSSSVLRSALGPDVVCRWWTSAITVAISWLQGDDAAVRSHFTEVERVPKA LEVTESPLVKAVFYACRAMHASLSGKADGQQNSFCHCERASGHLWSSLNVSGTTSDPSLN HVVQLLTCDLLLSLRTTLWQKQASASQLLGETYHASGTELAGFQRDLGSLRRLAHSFRPA YRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQNTKHGEVDTWPGQRERATAILLAC RHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCSDCQQMIVKLGGGTAIAAS |
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| Function | [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis.; [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates transcription of genes related to cholesterol synthesis pathway. | ||||
| Regulatory Network | |||||
| Full List of Metabolite(s) Regulating This Protein | ||||||
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| Organic acids and derivatives | ||||||
| Leucine | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
| Detailed Information |
Metabo Info
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| Regulating Pair |
Experim Info
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[1] | ||||
| Introduced Variation | Leucine addition (72 hours) | |||||
| Induced Change | SREBF2 mRNAlevel levels: increase | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Type 2 diabetes mellitus [ICD-11: 5A11] | |||||
| Details | It is reported that leucine addition causes the increase of SREBF2 mRNA levels compared with control group. | |||||
| References | |||||
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| 1 | Chronic exposure to leucine in vitro induces -cell dysfunction in INS-1E cells and mouse islets. J Endocrinol. 2012 Oct;215(1):79-88. | ||||
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