Details of Protein

General Information of Protein (ID: PRT01241)
Name MAP1 light chain 3-like protein 2 (MAP1LC3B)
Synonyms   Click to Show/Hide Synonyms of This Protein
Microtubule-associated proteins 1A/1B light chain 3B; Autophagy-related protein LC3 B; Autophagy-related ubiquitin-like modifier LC3 B; MAP1 light chain 3-like protein 2; MAP1A/MAP1B light chain 3 B; MAP1A/MAP1B LC3 B; Microtubule-associated protein 1 light chain 3 beta; MAP1LC3B; MAP1ALC3
Gene Name MAP1LC3B Gene ID
81631
UniProt ID
Q9GZQ8
Family Autophagy protein (Auto)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM
SELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFG
MKLSV
Structure
1V49 ; 2LUE ; 2N9X ; 2ZJD ; 3VTU ; 3VTV ; 3VTW ; 3WAO ; 3X0W ; 4WAA ; 5D94 ; 5DCN ; 5GMV ; 5MS2 ; 5MS5 ; 5MS6 ; 5V4K ; 5W9A ; 5XAC ; 5XAD ; 5XAE ; 6J04 ; 6LAN
Function Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Glutamine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glutamine addition (24 hours)
                      Induced Change MAP1LC3B protein expression levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Sepsis [ICD-11: 1G40]
                      Details It is reported that glutamine addition causes the increase of MAP1LC3B protein expression compared with control group.
References
1 Glutamine increases autophagy under Basal and stressed conditions in intestinal epithelial cells. Gastroenterology. 2009 Mar;136(3):924-32.

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