Details of Protein

General Information of Protein (ID: PRT01192)
Name Phosphodiesterase 4D (PDE4D)
Synonyms   Click to Show/Hide Synonyms of This Protein
DPDE3; PDE43; PDE4D; DPDE3
Gene Name PDE4D Gene ID
5144
UniProt ID
Q08499
Family Hydrolases (EC 3)
EC Number   EC: 3.1.4.53  (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric diester hydrolase
EC: 3.1.4.53
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MEAEGSSAPARAGSGEGSDSAGGATLKAPKHLWRHEQHHQYPLRQPQFRLLHPHHHLPPP
PPPSPQPQPQCPLQPPPPPPLPPPPPPPGAARGRYASSGATGRVRHRGYSDTERYLYCRA
MDRTSYAVETGHRPGLKKSRMSWPSSFQGLRRFDVDNGTSAGRSPLDPMTSPGSGLILQA
NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNF
AALTNLQDRAPSKRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHSV
SEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRP
MSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPL
TVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLST
PALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGF
KLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVL
LLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMC
DKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAP
DDPEEGRQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPL
DEQVEEEAVGEEEESQPEACVIDDRSPDT
Structure
1E9K ; 1MKD ; 1OYN ; 1PTW ; 1Q9M ; 1TB7 ; 1TBB ; 1XOM ; 1XON ; 1XOQ ; 1XOR ; 1Y2B ; 1Y2C ; 1Y2D ; 1Y2E ; 1Y2K ; 1ZKN ; 2FM0 ; 2FM5 ; 2PW3 ; 2QYN ; 3G4G ; 3G4I ; 3G4K ; 3G4L ; 3G58 ; 3IAD ; 3IAK ; 3K4S ; 3SL3 ; 3SL4 ; 3SL5 ; 3SL6 ; 3SL8 ; 3V9B ; 4OGB ; 4W1O ; 4WCU ; 5K1I ; 5K32 ; 5LBO ; 5TKB ; 5WH5 ; 5WH6 ; 5WQA ; 6AKR ; 6BOJ ; 6F6U ; 6F8R ; 6F8T ; 6F8U ; 6F8V ; 6F8W ; 6F8X ; 6FDC ; 6FDI ; 6FE7 ; 6FEB ; 6FET ; 6FT0 ; 6FTA ; 6FTW ; 6FW3 ; 6HWO ; 6IAG ; 6IBF ; 6IM6 ; 6IMB ; 6IMD ; 6IMI ; 6IMO ; 6IMR ; 6IMT ; 6IND ; 6INK ; 6INM ; 6KJZ ; 6KK0 ; 6NJH ; 6NJI ; 6NJJ ; 6RCW ; 6ZBA
Function Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Glutamine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glutamine absence (16 hours)
                      Induced Change PDE4D protein abundance levels: decrease (FC = 0.49)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Hepatocellular carcinoma [ICD-11: 2C12]
                      Details It is reported that glutamine absence causes the decrease of PDE4D protein abundance compared with control group.
References
1 Quantitative proteomics analysis reveals glutamine deprivation activates fatty acid -oxidation pathway in HepG2 cells. Amino Acids. 2016 May;48(5):1297-307.

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