Details of Protein
| General Information of Protein (ID: PRT01140) | |||||
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| Name | Alpha-ketoglutarate dehydrogenase (OGDH) | ||||
| Synonyms |
Click to Show/Hide Synonyms of This Protein
2-oxoglutarate dehydrogenase complex component E1; OGDC-E1; Alpha-ketoglutarate dehydrogenase; OGDH
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| Gene Name | OGDH | Gene ID | |||
| UniProt ID | |||||
| Family | Oxidoreductases (EC 1) | ||||
| EC Number | EC: 1.2.4.2 (Click to Show/Hide the Complete EC Tree) | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein | |||||
| Sequence |
MFHLRTCAAKLRPLTASQTVKTFSQNRPAAARTFQQIRCYSAPVAAEPFLSGTSSNYVEE
MYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLPLSRGSLAAVAHAQSLVEAQPNV DKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLDES DLDKVFHLPTTTFIGGQESALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFET PGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDKSSEN GVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDVKYHLGMYHRRINR VTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIV YETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDP EAVMYVCKVAAEWRSTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKY AELLVSQGVVNQPEYEEEISKYDKICEEAFARSKDEKILHIKHWLDSPWPGFFTLDGQPR SMSCPSTGLTEDILTHIGNVASSVPVENFTIHGGLSRILKTRGEMVKNRTVDWALAEYMA FGSLLKEGIHIRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSL SEYGVLGFELGFAMASPNALVLWEAQFGDFHNTAQCIIDQFICPGQAKWVRQNGIVLLLP HGMEGMGPEHSSARPERFLQMCNDDPDVLPDLKEANFDINQLYDCNWVVVNCSTPGNFFH VLRRQILLPFRKPLIIFTPKSLLRHPEARSSFDEMLPGTHFQRVIPEDGPAAQNPENVKR LLFCTGKVYYDLTRERKARDMVGQVAITRIEQLSPFPFDLLLKEVQKYPNAELAWCQEEH KNQGYYDYVKPRLRTTISRAKPVWYAGRDPAAAPATGNKKTHLTELQRLLDTAFDLDVFK NFS |
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| Structure | |||||
| Function | 2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex (OGDHC), which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. | ||||
| Regulatory Network | |||||
| Full List of Metabolite(s) Regulated by This Protein | ||||||
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| Organic acids and derivatives | ||||||
| 2-Hydroxyglutarate | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
| Detailed Information |
Metabo Info
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| Regulating Pair |
Experim Info
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[1] | ||||
| Introduced Variation | Knockout of OGDH | |||||
| Induced Change | 2-Hydroxyglutarate concentration: increase | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Cervical Cancer [ICD-11: 2C77] | |||||
| Details | It is reported that knockout of OGDH leads to the increase of 2-hydroxyglutarate levels compared with control group. | |||||
| Citric acid | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
| Detailed Information |
Metabo Info
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| Regulating Pair |
Experim Info
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[1] | ||||
| Introduced Variation | Knockout of OGDH | |||||
| Induced Change | Citric acid concentration: decrease | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Cervical Cancer [ICD-11: 2C77] | |||||
| Details | It is reported that knockout of OGDH leads to the decrease of citric acid levels compared with control group. | |||||
| Malic acid | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
| Detailed Information |
Metabo Info
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|||||
| Regulating Pair |
Experim Info
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[1] | ||||
| Introduced Variation | Knockout of OGDH | |||||
| Induced Change | Malic acid concentration: decrease | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Cervical Cancer [ICD-11: 2C77] | |||||
| Details | It is reported that knockout of OGDH leads to the decrease of malic acid levels compared with control group. | |||||
| Oxoglutaric acid | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
| Detailed Information |
Metabo Info
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|||||
| Regulating Pair |
Experim Info
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|
[1] | ||||
| Introduced Variation | Knockout of OGDH | |||||
| Induced Change | Oxoglutaric acid concentration: increase | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Cervical Cancer [ICD-11: 2C77] | |||||
| Details | It is reported that knockout of OGDH leads to the increase of oxoglutaric acid levels compared with control group. | |||||
| Succinic acid | Click to Show/Hide the Full List of Regulating Pair(s): 1 Pair(s) | |||||
| Detailed Information |
Metabo Info
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|
|||||
| Regulating Pair |
Experim Info
click to show the details of experiment for validating this pair
|
[1] | ||||
| Introduced Variation | Knockout of OGDH | |||||
| Induced Change | Succinic acid concentration: decrease | |||||
| Summary | Introduced Variation
Induced Change
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| Disease Status | Cervical Cancer [ICD-11: 2C77] | |||||
| Details | It is reported that knockout of OGDH leads to the decrease of succinic acid levels compared with control group. | |||||
| References | |||||
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| 1 | Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1 Stability in Aerobic Conditions. Cell Metab. 2016 Nov 8;24(5):740-752. | ||||
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