Details of Protein

General Information of Protein (ID: PRT01021)
Name Formimidoyltransferase-cyclodeaminase (FTCD)
Synonyms   Click to Show/Hide Synonyms of This Protein
Formiminotransferase-cyclodeaminase; FTCD; Ftcd
Gene Name Ftcd Gene ID
14317
UniProt ID
Q91XD4
Family Transferases (EC 2)
EC Number   EC: 2.1.2.5  (Click to Show/Hide the Complete EC Tree)
Transferase
Methylase
Hydroxymethyl-, formyl- and related transferase
EC: 2.1.2.5
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MSQLVECVPNFSEGNNQEVIDAISRAISQTPGCVLLDVDAGPSTNRTVYTFVGQPECVVE
GALHAARTASQLIDMSKHKGEHPRMGALDVCPFIPVRGVSMEECVLCAKAFGQRLAEELN
VPVYLYGEAAQTPSRQTLPAIRAGEYEALPEKLKQAEWVPDFGPSSFVPSWGATVTGARK
FLIAFNINLLSTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLEEKNLAQVSTNLLD
FEVTALHTVFEEARREAQELNLPVVGSQLVGLVPLKALLDAAAFYCDKEKLFVLEEEHRI
RLVVNRLGLDSLAPFDPKERIIEYLVPDSGPEQSLLDTSLRGFVREVGARSAAPGGGSVA
AAVAALGAALASMVGQMTYGRRQFDHLDSTMRRLIPPFHAASAQLTSLVDADARAFAACL
EAIKLPKNTPEERDRRACALQEGLRQAVAVPLKLAETVSQLWPALQELAHCGNLSCLSDL
QVAAKALETGVFGAYFNVLINLKDMTDDVFKEKTHHRISSLLQEAKTQAALVLGSLEARK
E
Function Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.; Binds and promotes bundling of vimentin filaments originating from the Golgi.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Methionine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Methionine decrease (504 hours)
                      Induced Change FTCD protein expression levels: decrease (FC = 0.18)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Fatty liver disease [ICD-11: DB92]
                      Details It is reported that methionine decrease causes the decrease of FTCD protein expression compared with control group.
References
1 Proteomic analysis of mice fed methionine and choline deficient diet reveals marker proteins associated with steatohepatitis. PLoS One. 2015 Apr 7;10(4):e0120577.

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