Details of Protein

General Information of Protein (ID: PRT01005)
Name Adenylate kinase isoenzyme 6 (AK6)
Synonyms   Click to Show/Hide Synonyms of This Protein
AK6; Coilin-interacting nuclear ATPase protein; Dual activity adenylate kinase/ATPase; AK/ATPase; Ak6; Cinap
Gene Name Ak6 Gene ID
102216272
UniProt ID
Q8VCP8
Family Transferases (EC 2)
EC Number   EC: 2.7.4.3  (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Phosphotransferase
EC: 2.7.4.3
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MKLPNILLTGTPGVGKTTLGKELASRSGLKYVNVGDLAREGQLYDGYDEEYGCPILDEDR
VVDELEHQMQEGGVIVDYHGCDFFPERWFHIVFVLRTDNGVLYKRLETRGYNEKKLQDNI
QCEIFQVLYEEAIASYKEEIVHQLPSNEPEQLEDNINQISKWIEQWVKDHNP
Function Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic oxygen compounds
            Glucose Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glucose (low concentration) addition (17.50 hours)
                      Induced Change AK6 protein abundance levels: increase (FC = 1.60)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Cerebral stroke [ICD-11: 8B11]
                      Details It is reported that low glucose addition causes the increase of AK6 protein abundance compared with control group.
References
1 Quantitative Proteomics Reveals the Beneficial Effects of Low Glucose on Neuronal Cell Survival in an in vitro Ischemic Penumbral Model. Front Cell Neurosci. 2020 Sep 1;14:272.

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