Details of Protein

General Information of Protein (ID: PRT00971)
Name Protein-tyrosine phosphatase 1B (PTPN1)
Synonyms   Click to Show/Hide Synonyms of This Protein
Protein-tyrosine phosphatase 1B; PTP-1B; PTPN1; PTP1B
Gene Name PTPN1 Gene ID
5770
UniProt ID
P18031
Family Hydrolases (EC 3)
EC Number   EC: 3.1.3.48  (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric monoester hydrolase
EC: 3.1.3.48
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
Structure
1A5Y ; 1AAX ; 1BZC ; 1BZH ; 1BZJ ; 1C83 ; 1C84 ; 1C85 ; 1C86 ; 1C87 ; 1C88 ; 1ECV ; 1EEN ; 1EEO ; 1G1F ; 1G1G ; 1G1H ; 1G7F ; 1G7G ; 1GFY ; 1I57 ; 1JF7 ; 1KAK ; 1KAV ; 1L8G ; 1LQF ; 1NL9 ; 1NNY ; 1NO6 ; 1NWE ; 1NWL ; 1NZ7 ; 1OEM ; 1OEO ; 1OES ; 1OET ; 1OEU ; 1OEV ; 1ONY ; 1ONZ ; 1PA1 ; 1PH0 ; 1PTT ; 1PTU ; 1PTV ; 1PTY ; 1PXH ; 1PYN ; 1Q1M ; 1Q6J ; 1Q6M ; 1Q6N ; 1Q6P ; 1Q6S ; 1Q6T ; 1QXK ; 1SUG ; 1T48 ; 1T49 ; 1T4J ; 1WAX ; 1XBO ; 2AZR ; 2B07 ; 2B4S ; 2BGD ; 2BGE ; 2CM2 ; 2CM3 ; 2CM7 ; 2CM8 ; 2CMA ; 2CMB ; 2CMC ; 2CNE ; 2CNF ; 2CNG ; 2CNH ; 2CNI ; 2F6F ; 2F6T ; 2F6V ; 2F6W ; 2F6Y ; 2F6Z ; 2F70 ; 2F71 ; 2FJM ; 2FJN ; 2H4G ; 2H4K ; 2HB1 ; 2HNP ; 2HNQ ; 2NT7 ; 2NTA ; 2QBP ; 2QBQ ; 2QBR ; 2QBS ; 2VEU ; 2VEV ; 2VEW ; 2VEX ; 2VEY ; 2ZMM ; 2ZN7 ; 3A5J ; 3A5K ; 3CWE ; 3D9C ; 3EAX ; 3EB1 ; 3EU0 ; 3I7Z ; 3I80 ; 3QKP ; 3QKQ ; 3SME ; 3ZMP ; 3ZMQ ; 3ZV2 ; 4BJO ; 4I8N ; 4QAH ; 4QAP ; 4QBE ; 4QBW ; 4Y14 ; 4ZRT ; 5K9V ; 5K9W ; 5KA0 ; 5KA1 ; 5KA2 ; 5KA3 ; 5KA4 ; 5KA7 ; 5KA8 ; 5KA9 ; 5KAA ; 5KAB ; 5KAC ; 5KAD ; 5QDE ; 5QDF ; 5QDG ; 5QDH ; 5QDI ; 5QDJ ; 5QDK ; 5QDL ; 5QDM ; 5QDN ; 5QDO ; 5QDP ; 5QDQ ; 5QDR ; 5QDS ; 5QDT ; 5QDU ; 5QDV ; 5QDW ; 5QDX ; 5QDY ; 5QDZ ; 5QE0 ; 5QE1 ; 5QE2 ; 5QE3 ; 5QE4 ; 5QE5 ; 5QE6 ; 5QE7 ; 5QE8 ; 5QE9 ; 5QEA ; 5QEB ; 5QEC ; 5QED ; 5QEE ; 5QEF ; 5QEG ; 5QEH ; 5QEI ; 5QEJ ; 5QEK ; 5QEL ; 5QEM ; 5QEN ; 5QEO ; 5QEP ; 5QEQ ; 5QER ; 5QES ; 5QET ; 5QEU ; 5QEV ; 5QEW ; 5QEX ; 5QEY ; 5QEZ ; 5QF0 ; 5QF1 ; 5QF2 ; 5QF3 ; 5QF4 ; 5QF5 ; 5QF6 ; 5QF7 ; 5QF8 ; 5QF9 ; 5QFA ; 5QFB ; 5QFC ; 5QFD ; 5QFE ; 5QFF ; 5QFG ; 5QFH ; 5QFI ; 5QFJ ; 5QFK ; 5QFL ; 5QFM ; 5QFN ; 5QFO ; 5QFP ; 5QFQ ; 5QFR ; 5QFS ; 5QFT ; 5QFU ; 5QFV ; 5QFW ; 5QFX ; 5QFY ; 5QFZ ; 5QG0 ; 5QG1 ; 5QG2 ; 5QG3 ; 5QG4 ; 5QG5 ; 5QG6 ; 5QG7 ; 5QG8 ; 5QG9 ; 5QGA ; 5QGB ; 5QGC ; 5QGD ; 5QGE ; 5QGF ; 5T19 ; 6B8E ; 6B8T ; 6B8X ; 6B8Z ; 6B90 ; 6B95 ; 6BAI ; 6CWU ; 6CWV ; 6NTP ; 6OL4 ; 6OLQ ; 6OLV ; 6OMY ; 6PFW ; 6PG0 ; 6PGT ; 6PHA ; 6PHS ; 6PM8
Function Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Glutamine Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glutamine addition (12 hours)
                      Induced Change PTPN1 protein expression levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Inflammatory bowel disease [ICD-11: DD72]
                      Details It is reported that glutamine addition causes the increase of PTPN1 protein expression compared with control group.
References
1 Proteomic analysis of glutamine-treated human intestinal epithelial HCT-8 cells under basal and inflammatory conditions. Proteomics. 2006 Jul;6(13):3926-37.

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