Details of Protein

General Information of Protein (ID: PRT00932)
Name Thioredoxin domain-containing protein 15 (TXNDC15)
Synonyms   Click to Show/Hide Synonyms of This Protein
Txndc15
Gene Name Txndc15 Gene ID
69672
UniProt ID
Q6P6J9
Family Thioredoxin (ThReDo)
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MQLLCWWQVLLWVLGLPAHGLEVAEDSGHPWREERPVPALQVGAVYLHEEEVAQDHRDQA
RAAEPMEASLGPRGDPMVVLSVVPGAAEDQRSPEAHDGTCSAQGEEDPSCGRENLFGLQG
AGGFQDREEEYYAEPGVTEAEPVATEDANSTDSLKSPKVNCEERNVTGLENFTLKILNMS
QDLMDFLNPNGSDCTLVLFYTPWCRFSASLAPHFNSLPRAFPTLGFLALDASQHSSLSTR
FGTVAVPNILLFQGAKPMARFNHTDRTLETLKIFIFNQTGIEAKKNVVVTQADQMGPLPS
TLIKTVDWLLVFSLFFLISFIMYATIRTESIRWLIPGQEQEHAE
Function Acts as a positive regulator of ciliary hedgehog signaling. Required for cilia biogenesis.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic oxygen compounds
            Glucose Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Glucose (low concentration) addition (17.50 hours)
                      Induced Change TXNDC15 protein abundance levels: increase (FC = 1.68)
                      Summary Introduced Variation         Induced Change 
                      Disease Status Cerebral stroke [ICD-11: 8B11]
                      Details It is reported that low glucose addition causes the increase of TXNDC15 protein abundance compared with control group.
References
1 Quantitative Proteomics Reveals the Beneficial Effects of Low Glucose on Neuronal Cell Survival in an in vitro Ischemic Penumbral Model. Front Cell Neurosci. 2020 Sep 1;14:272.

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