Details of Protein

General Information of Protein (ID: PRT00823)
Name Coenzyme Q protein 8A (COQ8A)
Synonyms   Click to Show/Hide Synonyms of This Protein
Chaperone activity of bc1 complex-like; Chaperone-ABC1-like; Atypical kinase COQ8A, mitochondrial; aarF domain-containing protein kinase 3; Coq8a; Adck3; Cabc1
Gene Name Coq8a Gene ID
360887
UniProt ID
Q5BJQ0
Family Transferases (EC 2)
EC Number   EC: 2.7.-.-  (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
.
EC: 2.7.-.-
  Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Function) of This Protein
Sequence
MAAMLGDAIMVAKGLAKLTQAAVETHLQNLGLGGELILAARALQSTAVEQISMVFGKVQG
QDKHEDSYATENFEDLEAEVQFSTPQAAGSSPDFSTASSLDQPLSSSLGHAHREGPAPAY
VSSGPFREAGLSGQATSPLGRVNGRLFVDCRDLFLANSIQRRFFHQDQAPVGGLTAEDIE
KARQAKARPESKPHKQMLSERARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRS
ENSTGKKAVLDSSPFLSEANAERIVSTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFER
VRQSADFMPLKQMTKTLNNDLGPHWRDKLEYFEERPFAAASIGQVHLARLKGGREVAMKI
QYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELTLECDYQREAAYAKKFR
ELLKDHPFFYVPEIVDELCSPHVLTTELITGFPLDQAEGLSQEVRNEICYNILVLCLREL
FEFHVMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQVIRAAADQDREAVLK
KSIEMKFLTGYEVKAMEDAHLDAILILGEAFASEEPFDFGTQSTTEKIHNLIPIMLKHRL
IPPPEETYSLHRKMGGSFLICSKLKACFPCKAMFEEAYSNYCRMKSGLQ
Function Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates. Shows an unusual selectivity for binding ADP over ATP.
Regulatory Network
Full List of Metabolite(s) Regulating This Protein
      Organic acids and derivatives
            Citrulline Click to Show/Hide the Full List of Regulating Pair(s):   1 Pair(s)
               Detailed Information Metabo  Info click to show the details of this metabolite
               Regulating Pair Experim Info click to show the details of experiment for validating this pair [1]
                      Introduced Variation Citrulline addition (1336 hours)
                      Induced Change COQ8A protein expression levels: increase
                      Summary Introduced Variation         Induced Change 
                      Disease Status Healthy individual
                      Details It is reported that citrulline addition causes the increase of COQ8A protein expression compared with control group.
References
1 Citrulline Supplementation Induces Changes in Body Composition and Limits Age-Related Metabolic Changes in Healthy Male Rats. J Nutr. 2015 Jul;145(7):1429-37.

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